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EMC3 Emc3p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853628, updated on 18-Sep-2024

Summary

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Official Symbol
EMC3
Official Full Name
Emc3p
Primary source
SGD:S000001690
Locus tag
YKL207W
See related
AllianceGenome:SGD:S000001690; FungiDB:YKL207W; VEuPathDB:YKL207W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
AIM27
Summary
Involved in protein folding in endoplasmic reticulum. Part of EMC complex. Orthologous to human EMC3 (ER membrane protein complex subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See EMC3 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (48194..48955)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene tRNA-Thr Neighboring gene Cbt1p Neighboring gene Add66p Neighboring gene Ran GTPase-binding protein LOS1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A conserved endoplasmic reticulum membrane protein complex (EMC) facilitates phospholipid transfer from the ER to mitochondria. Lahiri S, et al. PLoS Biol, 2014 Oct. PMID 25313861, Free PMC Article
  2. Structure of the ER membrane complex, a transmembrane-domain insertase. Bai L, et al. Nature, 2020 Aug. PMID 32494008, Free PMC Article
  3. Biosynthesis of ionotropic acetylcholine receptors requires the evolutionarily conserved ER membrane complex. Richard M, et al. Proc Natl Acad Sci U S A, 2013 Mar 12. PMID 23431131, Free PMC Article
  4. Evidence for interaction between Hsp90 and the ER membrane complex. Kudze T, et al. Cell Stress Chaperones, 2018 Sep. PMID 29808299, Free PMC Article
  5. Secretory pathway genes assessed by high-throughput microscopy and synthetic genetic array analysis. Bircham PW, et al. Mol Biosyst, 2011 Sep. PMID 21731954

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in protein folding in endoplasmic reticulum HGI PubMed 
Component Evidence Code Pubs
part_of EMC complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of EMC complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Emc3p
NP_012715.3
  • Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; required for respiratory growth; null mutant displays induction of the unfolded protein response; homologous to worm Y62E10A.10/EMC-3, fly CG6750, human TMEM111

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    48194..48955
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179772.1 → NP_012715.3  TPA: Emc3p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012715.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A7A082, D6VWZ6, P36039, Q86ZT1
    UniProtKB/TrEMBL
    G2WHI7
    Conserved Domains (1) summary
    pfam01956
    Location:2 → 194
    DUF106; Integral membrane protein DUF106
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P36039.3

Gene LinkOut

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