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MIA40 Mia40p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853639, updated on 2-Nov-2024

Summary

Official Symbol
MIA40
Official Full Name
Mia40p
Primary source
SGD:S000001678
Locus tag
YKL195W
See related
AllianceGenome:SGD:S000001678; FungiDB:YKL195W; VEuPathDB:YKL195W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
FMP15; TIM40
Summary
Enables 2 iron, 2 sulfur cluster binding activity; protein disulfide isomerase activity; and thiol oxidase activity. Involved in protein folding and protein import into mitochondrial intermembrane space. Located in mitochondrial inner membrane. Is active in mitochondrial intermembrane space. Used to study mitochondrial complex I deficiency. Orthologous to human CHCHD4 (coiled-coil-helix-coiled-coil-helix domain containing 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See MIA40 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (75821..77032)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene tRNA-Asn Neighboring gene palmitoyltransferase YKT6 Neighboring gene threonine--tRNA ligase MST1 Neighboring gene type 1 protein phosphatase-activating protein SDS22

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 2 iron, 2 sulfur cluster binding IDA
Inferred from Direct Assay
more info
PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein disulfide isomerase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein-disulfide reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein-disulfide reductase activity IEA
Inferred from Electronic Annotation
more info
 
enables thiol oxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in mitochondrial intermembrane space IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in mitochondrial intermembrane space IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial intermembrane space IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Mia40p
NP_012726.2
  • Import and assembly protein in mitochondrial intermembrane space; component of MIA pathway which mediates import and oxidative folding of substrates including small proteins containing twin cysteine motifs; acts in concert with Erv1p, which oxidizes the cysteine residues of Mia40p to comprise a disulfide relay system that catalyzes import; also mediates folding of Atp23p via a chaperone-like activity; forms a dimer that binds iron-sulfur cluster in vitro

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    75821..77032
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179761.1NP_012726.2  TPA: Mia40p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012726.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VX05, P36046
    UniProtKB/TrEMBL
    A6ZZD0, B3LQR0, C7GJ14, C8ZBY1, G2WHJ7
    Conserved Domains (2) summary
    COG5271
    Location:78248
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    pfam06747
    Location:307343
    CHCH; CHCH domain