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CNB1 calcineurin regulatory subunit B [ Saccharomyces cerevisiae S288C ]

Gene ID: 853644, updated on 2-Nov-2024

Summary

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Official Symbol
CNB1
Official Full Name
calcineurin regulatory subunit B
Primary source
SGD:S000001673
Locus tag
YKL190W
See related
AllianceGenome:SGD:S000001673; FungiDB:YKL190W; VEuPathDB:YKL190W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CRV1; YCN2
Summary
Enables calcium ion binding activity. Contributes to calcium-dependent protein serine/threonine phosphatase activity. Involved in several processes, including cellular response to pheromone; conjugation with cellular fusion; and fungal-type cell wall organization. Part of calcineurin complex. Human ortholog(s) of this gene implicated in Alzheimer's disease and dilated cardiomyopathy. Orthologous to several human genes including PPP3R1 (protein phosphatase 3 regulatory subunit B, alpha). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See CNB1 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
2
Sequence:
Chromosome: XI; NC_001143.9 (82947..83550)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene acyl carrier protein Neighboring gene 2-(3-amino-3-carboxypropyl)histidine synthase Neighboring gene tRNA-Leu Neighboring gene Hym1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. cDNA cloning of a calcineurin B homolog in Saccharomyces cerevisiae. Kuno T, et al. Biochem Biophys Res Commun, 1991 Oct 31. PMID 1659397
  2. Myristoylation of calcineurin B is not required for function or interaction with immunophilin-immunosuppressant complexes in the yeast Saccharomyces cerevisiae. Zhu D, et al. J Biol Chem, 1995 Oct 20. PMID 7559604
  3. Calcineurin promotes adaptation to chronic stress through two distinct mechanisms. Flynn MJ, et al. Mol Biol Cell, 2024 Oct 1. PMID 39083354,
  4. Screening for a gene deletion mutant whose temperature sensitivity is suppressed by FK506 in budding yeast and its application for a positive screening for drugs inhibiting calcineurin. Kume K, et al. Biosci Biotechnol Biochem, 2015. PMID 25614218
  5. The protein phosphatase calcineurin is essential for NaCl tolerance of Saccharomyces cerevisiae. Mendoza I, et al. J Biol Chem, 1994 Mar 25. PMID 8132612

See all (168) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Calcineurin-dependent regulation of endocytosis by a plasma membrane ubiquitin ligase adaptor, Rcr1.
    Title: Calcineurin-dependent regulation of endocytosis by a plasma membrane ubiquitin ligase adaptor, Rcr1.
  2. Results reveal that EF1, EF2, and EF3 of CNB1 stimulate phosphatase activity independent of known conformational changes induced upon Ca2+ binding that lead to calmodulin binding and relief of bipartite auto-inhibition mediated by C-terminus of CNA. Also, the study indicates that distinct Cnb1 EF hand domains differentially affect calcineurin function, and that EF4 is not essential despite conservation across taxa.
    Title: Calcineurin Regulatory Subunit Calcium-Binding Domains Differentially Contribute to Calcineurin Signaling in Saccharomyces cerevisiae.
  3. The regulatory component of calcineurin, Cnb1, is essential for cell survival under compressive mechanical stress.
    Title: Protein kinase C and calcineurin cooperatively mediate cell survival under compressive mechanical stress.
  4. Hsp90 prevented the death of calcineurin- and Cmk2-deficient cells.
    Title: Nonapoptotic death of Saccharomyces cerevisiae cells that is stimulated by Hsp90 and inhibited by calcineurin and Cmk2 in response to endoplasmic reticulum stresses.
  5. target of rapamycin complex 2(TORC2)-SLM signaling negatively regulates calcineurin, and calcineurin negatively regulates TORC2-SLM
    Title: Mutual antagonism of target of rapamycin and calcineurin signaling.
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Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables calcium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to calcium-dependent protein serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium-dependent protein serine/threonine phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-dependent protein serine/threonine phosphatase regulator activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in calcineurin-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to pheromone IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in conjugation with cellular fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fungal-type cell wall organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular monoatomic ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of calcineurin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of calcineurin complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
calcineurin regulatory subunit B
NP_012731.1
  • Calcineurin B; regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (stress-response transcription factor); other calcineurin subunit encoded by CNA1 and/or CMP1; regulates function of Aly1p alpha-arrestin; myristoylation by Nmt1p reduces calcineurin activity in response to submaximal Ca signals, is needed to prevent constitutive phosphatase activity; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    82947..83550
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179756.1 → NP_012731.1  TPA: calcineurin regulatory subunit B [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012731.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VX10, P25296
    UniProtKB/TrEMBL
    A6ZZD5, B3LQR5, C8ZBY6, G2WHK2, N1NZL4
    Conserved Domains (1) summary
    COG5126
    Location:4 → 161
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25296.3

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