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LOT5 Lot5p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853652, updated on 18-Sep-2024

Summary

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Official Symbol
LOT5
Official Full Name
Lot5p
Primary source
SGD:S000001666
Locus tag
YKL183W
See related
AllianceGenome:SGD:S000001666; FungiDB:YKL183W; VEuPathDB:YKL183W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to be involved in mRNA cis splicing, via spliceosome. Located in cytoplasm and nucleus. Orthologous to human CLNS1A (chloride nucleotide-sensitive channel 1A). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See LOT5 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (98721..99641)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene ornithine decarboxylase SPE1 Neighboring gene uncharacterized protein Neighboring gene tetrafunctional fatty acid synthase subunit FAS1 Neighboring gene ribose phosphate diphosphokinase subunit PRS1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Multiple mechanisms regulate expression of low temperature responsive (LOT) genes in Saccharomyces cerevisiae. Zhang L, et al. Biochem Biophys Res Commun, 2001 May 4. PMID 11327734
  2. Modulation of Ubc4p/Ubc5p-mediated stress responses by the RING-finger-dependent ubiquitin-protein ligase Not4p in Saccharomyces cerevisiae. Mulder KW, et al. Genetics, 2007 May. PMID 17513889, Free PMC Article
  3. Transcriptome-wide binding sites for components of the Saccharomyces cerevisiae non-poly(A) termination pathway: Nrd1, Nab3, and Sen1. Creamer TJ, et al. PLoS Genet, 2011 Oct. PMID 22028667, Free PMC Article
  4. Complete DNA sequence of yeast chromosome XI. Dujon B, et al. Nature, 1994 Jun 2. PMID 8196765
  5. A role for the budding yeast separase, Esp1, in Ty1 element retrotransposition. Ho KL, et al. PLoS Genet, 2015 Mar. PMID 25822502, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in mRNA cis splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spliceosomal snRNP assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of pICln-Sm protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Lot5p
NP_012738.1
  • hypothetical protein; gene expression increases in cultures shifted to a lower temperature; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    98721..99641
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179749.1 → NP_012738.1  TPA: Lot5p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012738.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VX18, P34234
    UniProtKB/TrEMBL
    B3LQS3, C7GJ27, G2WHL0, N1P2V5
    Conserved Domains (1) summary
    pfam03517
    Location:83 → 216
    Voldacs; Regulator of volume decrease after cellular swelling
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34234.1

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