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uncharacterized protein [ Saccharomyces cerevisiae S288C ]

Gene ID: 853658, updated on 2-Nov-2024

Summary

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Official Full Name
uncharacterized protein
Primary source
SGD:S000001705
Locus tag
YKL222C
See related
AllianceGenome:SGD:S000001705; FungiDB:YKL222C; VEuPathDB:YKL222C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables sequence-specific DNA binding activity. Predicted to be involved in DNA-templated transcription and regulation of transcription by RNA polymerase II. Located in mitotic spindle and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (3503..5620, complement)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene seripauperin PAU16 Neighboring gene Mch2p Neighboring gene ferric/cupric-chelate reductase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Phenotypic analysis of genes encoding yeast zinc cluster proteins. Akache B, et al. Nucleic Acids Res, 2001 May 15. PMID 11353088, Free PMC Article
  2. High-resolution DNA-binding specificity analysis of yeast transcription factors. Zhu C, et al. Genome Res, 2009 Apr. PMID 19158363, Free PMC Article
  3. An overexpression screen in Saccharomyces cerevisiae identifies novel genes that affect endocytic protein trafficking. Arlt H, et al. Traffic, 2011 Nov. PMID 21777356
  4. Systematic identification and functional screens of uncharacterized proteins associated with eukaryotic ribosomal complexes. Fleischer TC, et al. Genes Dev, 2006 May 15. PMID 16702403, Free PMC Article
  5. Ist2 recruits the lipid transporters Osh6/7 to ER-PM contacts to maintain phospholipid metabolism. Wong AKO, et al. J Cell Biol, 2021 Sep 6. PMID 34259806, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding HDA PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitotic spindle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
uncharacterized protein
NP_012700.1
  • hypothetical protein; may interact with ribosomes, based on co-purification experiments; similar to transcriptional regulators from the zinc cluster (binuclear cluster) family; null mutant is sensitive to caffeine

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    3503..5620 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179787.1 → NP_012700.1  TPA: uncharacterized protein YKL222C [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012700.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWY1, P35995
    UniProtKB/TrEMBL
    A7A067, B3LQN7, G2WHH2
    Conserved Domains (2) summary
    smart00066
    Location:18 → 59
    GAL4; GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain
    pfam04082
    Location:200 → 463
    Fungal_trans; Fungal specific transcription factor domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P35995.1

Gene LinkOut

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