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LST4 Lst4p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853678, updated on 2-Nov-2024

Summary

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Official Symbol
LST4
Official Full Name
Lst4p
Primary source
SGD:S000001659
Locus tag
YKL176C
See related
AllianceGenome:SGD:S000001659; FungiDB:YKL176C; VEuPathDB:YKL176C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Contributes to GTPase activator activity. Involved in cellular response to amino acid stimulus and positive regulation of TORC1 signaling. Located in vacuolar membrane. Part of FNIP-folliculin RagC/D GAP. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See LST4 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (115500..117986, complement)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Coy1p Neighboring gene Ste3p Neighboring gene Zn(2+) transporter ZRT3 Neighboring gene Tpo5p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular specificity, convergence and constraint shape adaptive evolution in nutrient-poor environments. Hong J, et al. PLoS Genet, 2014 Jan. PMID 24415948, Free PMC Article
  2. Yeast genes involved in regulating cysteine uptake affect production of hydrogen sulfide from cysteine during fermentation. Huang CW, et al. FEMS Yeast Res, 2017 Aug 1. PMID 28810701
  3. Amino Acids Stimulate TORC1 through Lst4-Lst7, a GTPase-Activating Protein Complex for the Rag Family GTPase Gtr2. Péli-Gulli MP, et al. Cell Rep, 2015 Oct 6. PMID 26387955
  4. Different ubiquitin signals act at the Golgi and plasma membrane to direct GAP1 trafficking. Risinger AL, et al. Mol Biol Cell, 2008 Jul. PMID 18434603, Free PMC Article
  5. Feedback Inhibition of the Rag GTPase GAP Complex Lst4-Lst7 Safeguards TORC1 from Hyperactivation by Amino Acid Signals. Péli-Gulli MP, et al. Cell Rep, 2017 Jul 11. PMID 28700931

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Amino acids stimulate TORC1 through Lst4-Lst7, a GTPase-activating protein complex for the Rag family GTPase Gtr2.
    Title: Amino Acids Stimulate TORC1 through Lst4-Lst7, a GTPase-Activating Protein Complex for the Rag Family GTPase Gtr2.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to GTPase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in amino acid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to amino acid stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of TORC1 signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of FNIP-folliculin RagC/D GAP IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol HDA PubMed 
located_in vacuolar membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Lst4p
NP_012745.1
  • Subunit of the Lst4p-Lst7p GTPase activating protein complex for Gtr2p; stimulates the GTPase activity of Rag family GTPase Gtr2p, within the context of the Gtr1p-Gtr2p heterodimer, after amino acid stimulation; required for activation of TORC1 in response to amino acid stimulation; recruited to the vacuolar membrane during amino acid starvation and released from the membrane by TORC1; required for the transport of amino acid permease Gap1p from the Golgi to the cell surface

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    115500..117986 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179742.1 → NP_012745.1  TPA: Lst4p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012745.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VX24, P34239
    UniProtKB/TrEMBL
    B3LQS9, C8ZBZ9, N1NZM7
    Conserved Domains (1) summary
    pfam18639
    Location:118 → 288
    Longin_2; Yeast longin domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34239.1

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