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TPO5 Tpo5p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853680, updated on 2-Nov-2024

Summary

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Official Symbol
TPO5
Official Full Name
Tpo5p
Primary source
SGD:S000001657
Locus tag
YKL174C
See related
AllianceGenome:SGD:S000001657; FungiDB:YKL174C; VEuPathDB:YKL174C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables polyamine transmembrane transporter activity. Involved in polyamine transport. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See TPO5 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (120380..122236, complement)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Lst4p Neighboring gene Zn(2+) transporter ZRT3 Neighboring gene U5 snRNP GTPase SNU114 Neighboring gene Ebp2p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Excretion of putrescine and spermidine by the protein encoded by YKL174c (TPO5) in Saccharomyces cerevisiae. Tachihara K, et al. J Biol Chem, 2005 Apr 1. PMID 15668236
  2. Metabolic engineering of Saccharomyces cerevisiae for itaconic acid production. Blazeck J, et al. Appl Microbiol Biotechnol, 2014 Oct. PMID 24997118
  3. A two-hybrid screen of the yeast proteome for Hsp90 interactors uncovers a novel Hsp90 chaperone requirement in the activity of a stress-activated mitogen-activated protein kinase, Slt2p (Mpk1p). Millson SH, et al. Eukaryot Cell, 2005 May. PMID 15879519, Free PMC Article
  4. Heterozygous screen in Saccharomyces cerevisiae identifies dosage-sensitive genes that affect chromosome stability. Strome ED, et al. Genetics, 2008 Mar. PMID 18245329, Free PMC Article
  5. Annotating novel genes by integrating synthetic lethals and genomic information. Schöner D, et al. BMC Syst Biol, 2008 Jan 14. PMID 18194531, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. YKL174c (TPO5) has a role in excretion of putrescine and spermidine
    Title: Excretion of putrescine and spermidine by the protein encoded by YKL174c (TPO5) in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables gamma-aminobutyric acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables polyamine transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in amino acid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in gamma-aminobutyric acid transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in polyamine transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in polyamine transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Tpo5p
NP_012747.1
  • Protein involved in excretion of putrescine and spermidine; putative polyamine transporter in the Golgi or post-Golgi vesicles

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    120380..122236 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179740.1 → NP_012747.1  TPA: Tpo5p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012747.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VX26, P36029
    UniProtKB/TrEMBL
    A6ZZF1, B3LQT1, C7GJ35, C8ZC00, G2WHL8, N1P136
    Conserved Domains (1) summary
    pfam00324
    Location:59 → 531
    AA_permease; Amino acid permease
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P36029.1

Gene LinkOut

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