U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

NNK1 protein kinase NNK1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853683, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
NNK1
Official Full Name
protein kinase NNK1
Primary source
SGD:S000001654
Locus tag
YKL171W
See related
AllianceGenome:SGD:S000001654; FungiDB:YKL171W; VEuPathDB:YKL171W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables protein kinase activity. Involved in proteolysis. Located in cytoplasm. Orthologous to human MKNK1 (MAPK interacting serine/threonine kinase 1). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See NNK1 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (127475..130261)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene U5 snRNP GTPase SNU114 Neighboring gene Ebp2p Neighboring gene mitochondrial 54S ribosomal protein YmL38/YmL34 Neighboring gene putative serine/threonine protein kinase KKQ8

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Systematic screening of protein modifications in four kinases using affinity enrichment and mass spectrometry analysis with unrestrictive sequence alignment. Zhang K, et al. Anal Chim Acta, 2011 Apr 8. PMID 21458632
  2. Mitochondrial protein phosphorylation: lessons from yeasts. Tomaska L. Gene, 2000 Sep 5. PMID 10974565
  3. Saccharomyces cerevisiae gene YMR291W/TDA1 mediates the in vivo phosphorylation of hexokinase isoenzyme 2 at serine-15. Kettner K, et al. FEBS Lett, 2012 Feb 17. PMID 22289182
  4. Classification and functional annotation of eukaryotic protein kinases. Miranda-Saavedra D, et al. Proteins, 2007 Sep 1. PMID 17557329
  5. Quantification of oxidative stress phenotypes based on high-throughput growth profiling of protein kinase and phosphatase knockouts. Altıntaş A, et al. FEMS Yeast Res, 2016 Feb. PMID 26564984

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium/calmodulin-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity HDA PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
protein kinase NNK1
NP_012750.1
  • Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    127475..130261
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179737.1 → NP_012750.1  TPA: protein kinase NNK1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012750.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VX29, P36003
    UniProtKB/TrEMBL
    G2WHM1, N1NZM9
    Conserved Domains (2) summary
    cd00180
    Location:455 → 613
    PKc; Catalytic domain of Protein Kinases
    cl21453
    Location:817 → 864
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P36003.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools