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PIR1 beta-1,3-glucan linked protein [ Saccharomyces cerevisiae S288C ]

Gene ID: 853692, updated on 2-Nov-2024

Summary

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Official Symbol
PIR1
Official Full Name
beta-1,3-glucan linked protein
Primary source
SGD:S000001647
Locus tag
YKL164C
See related
AllianceGenome:SGD:S000001647; FungiDB:YKL164C; VEuPathDB:YKL164C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CCW6
Summary
A structural constituent of cell wall. Involved in fungal-type cell wall organization and intracellular protein transport. Located in cellular bud scar and nuclear periphery. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See PIR1 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (141794..142819, complement)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene mannose-ethanolamine phosphotransferase MCD4 Neighboring gene tRNA-Glu Neighboring gene beta-1,3-glucan linked protein Neighboring gene type II protein arginine methyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Construction of a novel Pichia pastoris cell-surface display system based on the cell wall protein Pir1. Wang Q, et al. Curr Microbiol, 2008 Apr. PMID 18188644
  2. Pir1p mediates translocation of the yeast Apn1p endonuclease into the mitochondria to maintain genomic stability. Vongsamphanh R, et al. Mol Cell Biol, 2001 Mar. PMID 11238901, Free PMC Article
  3. The contribution of the O-glycosylated protein Pir2p/Hsp150 to the construction of the yeast cell wall in wild-type cells and beta 1,6-glucan-deficient mutants. Kapteyn JC, et al. Mol Microbiol, 1999 Mar. PMID 10209754
  4. Three yeast genes, PIR1, PIR2 and PIR3, containing internal tandem repeats, are related to each other, and PIR1 and PIR2 are required for tolerance to heat shock. Toh-e A, et al. Yeast, 1993 May. PMID 8322511
  5. ATPase activity of a yeast secretory glycoprotein allows ER exit during inactivation of COPII components Sec24p and Sec13p. Suntio T, et al. Yeast, 2011 Jun. PMID 21446055

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that bud scars contain proteins like Pir1p as internal components.
    Title: Comparison of cell wall localization among Pir family proteins and functional dissection of the region required for cell wall binding and bud scar recruitment of Pir1p.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables structural constituent of cell wall IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of cell wall IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of cell wall IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell wall organization IEA
Inferred from Electronic Annotation
more info
  
involved_in fungal-type cell wall organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fungal-type cell wall organization IEA
Inferred from Electronic Annotation
more info
  
involved_in fungal-type cell wall organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular protein transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cellular bud scar IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in fungal-type cell wall IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in fungal-type cell wall IDA
Inferred from Direct Assay
more info
 PubMed 
located_in fungal-type cell wall IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear periphery IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
beta-1,3-glucan linked protein
NP_012757.1
  • O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle; PIR1 has a paralog, YJL160C, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    141794..142819 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179730.1 → NP_012757.1  TPA: beta-1,3-glucan linked protein [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012757.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6ZZG0, D6VX35, Q03178
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03178.1

Gene LinkOut

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