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RCN1 Rcn1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853698, updated on 2-Nov-2024

Summary

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Official Symbol
RCN1
Official Full Name
Rcn1p
Primary source
SGD:S000001642
Locus tag
YKL159C
See related
AllianceGenome:SGD:S000001642; FungiDB:YKL159C; VEuPathDB:YKL159C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables calcium-dependent protein serine/threonine phosphatase regulator activity and protein phosphatase 2B binding activity. Involved in calcium-mediated signaling. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human RCAN3 (RCAN family member 3); RCAN1 (regulator of calcineurin 1); and RCAN2 (regulator of calcineurin 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See RCN1 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (153816..154451, complement)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene putative protein kinase KDX1 Neighboring gene Elf1p Neighboring gene metallo-aminopeptidase Neighboring gene ribosomal 40S subunit protein S27A

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification and characterization of a highly conserved calcineurin binding protein, CBP1/calcipressin, in Cryptococcus neoformans. Görlach J, et al. EMBO J, 2000 Jul 17. PMID 10899116, Free PMC Article
  2. GSK-3 kinases enhance calcineurin signaling by phosphorylation of RCNs. Hilioti Z, et al. Genes Dev, 2004 Jan 1. PMID 14701880, Free PMC Article
  3. Elucidating the Candida albicans calcineurin signaling cascade controlling stress response and virulence. Reedy JL, et al. Fungal Genet Biol, 2010 Feb. PMID 19755168, Free PMC Article
  4. Identification of RCN1 and RSA3 as ethanol-tolerant genes in Saccharomyces cerevisiae using a high copy barcoded library. Anderson MJ, et al. FEMS Yeast Res, 2012 Feb. PMID 22093065
  5. Domain architecture of the regulators of calcineurin (RCANs) and identification of a divergent RCAN in yeast. Mehta S, et al. Mol Cell Biol, 2009 May. PMID 19273587, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The authors find that increased dosage of either RCN1 or RSA3 improves tolerance of S288C and M2 to toxic levels of ethanol.
    Title: Identification of RCN1 and RSA3 as ethanol-tolerant genes in Saccharomyces cerevisiae using a high copy barcoded library.
  2. identify the molecular mechanism of Rcn1 phosphorylation-induced stimulation of the phosphatase activity of calcineurin
    Title: The SCFCdc4 ubiquitin ligase regulates calcineurin signaling through degradation of phosphorylated Rcn1, an inhibitor of calcineurin.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables calcium-dependent protein serine/threonine phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-dependent protein serine/threonine phosphatase regulator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein phosphatase 2B binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcium-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium-mediated signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in calcium-mediated signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IC
Inferred by Curator
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Rcn1p
NP_012763.1
  • Protein involved in calcineurin regulation during calcium signaling; has similarity to H. sapiens DSCR1 which is found in the Down Syndrome candidate region

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    153816..154451 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179725.1 → NP_012763.1  TPA: Rcn1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012763.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VX40, P36054
    UniProtKB/TrEMBL
    A6ZZG5, B3LQU6, B5VM07, C7GT77, C8ZC16, G2WHN2, N1P8A7
    Conserved Domains (1) summary
    pfam04847
    Location:17 → 201
    Calcipressin
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P36054.1

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