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SRP102 Signal recognition particle receptor subunit beta [ Saccharomyces cerevisiae S288C ]

Gene ID: 853702, updated on 2-Nov-2024

Summary

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Official Symbol
SRP102
Official Full Name
Signal recognition particle receptor subunit beta
Primary source
SGD:S000001637
Locus tag
YKL154W
See related
AllianceGenome:SGD:S000001637; FungiDB:YKL154W; VEuPathDB:YKL154W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables signal recognition particle binding activity. Involved in protein targeting to ER. Located in endoplasmic reticulum membrane. Part of signal recognition particle receptor complex. Orthologous to human SRPRB (SRP receptor subunit beta). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See SRP102 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (161601..162335)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene ribosomal 40S subunit protein S27A Neighboring gene tRNA methyltransferase RSM22 Neighboring gene tRNA-Arg Neighboring gene phosphoglycerate mutase GPM1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural basis for the function of the beta subunit of the eukaryotic signal recognition particle receptor. Schwartz T, et al. Cell, 2003 Mar 21. PMID 12654246
  2. Homodimerization of the G protein SRbeta in the nucleotide-free state involves proline cis/trans isomerization in the switch II region. Schwartz TU, et al. Proc Natl Acad Sci U S A, 2006 May 2. PMID 16627619, Free PMC Article
  3. The beta subunit of the signal recognition particle receptor is a transmembrane GTPase that anchors the alpha subunit, a peripheral membrane GTPase, to the endoplasmic reticulum membrane. Miller JD, et al. J Cell Biol, 1995 Feb. PMID 7844142, Free PMC Article
  4. A functional GTPase domain, but not its transmembrane domain, is required for function of the SRP receptor beta-subunit. Ogg SC, et al. J Cell Biol, 1998 Jul 27. PMID 9679135, Free PMC Article
  5. Mass-murder deletion of 19 ORFs from Saccharomyces cerevisiae chromosome XI. Vandenbol M, et al. Gene, 2000 Apr 18. PMID 10773443

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results describe the 2.2-A crystal structure of the nucleotide-free signal-recognition particle receptor beta domain.
    Title: Homodimerization of the G protein SRbeta in the nucleotide-free state involves proline cis/trans isomerization in the switch II region.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables signal recognition particle binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein targeting to ER IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein targeting to ER IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of signal recognition particle receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of signal recognition particle receptor complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
Signal recognition particle receptor subunit beta
NP_012768.1
  • Signal recognition particle (SRP) receptor beta subunit; involved in SRP-dependent protein targeting; anchors the alpha subunit, Srp101p to the ER membrane

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    161601..162335
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179720.1 → NP_012768.1  TPA: Signal recognition particle receptor subunit beta [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012768.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VX44, P36057
    UniProtKB/TrEMBL
    A6ZZG9, B3LQU8, C7GT79, C8ZC21, G2WHN6, N1NZN9
    Conserved Domains (1) summary
    pfam09439
    Location:36 → 221
    SRPRB; Signal recognition particle receptor beta subunit
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P36057.1

Gene LinkOut

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