DBR1 RNA lariat debranching enzyme [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: DBR1
Official Full Name: RNA lariat debranching enzyme
Primary source: SGD:S000001632
Locus tag: YKL149C
See related: AllianceGenome:SGD:S000001632; FungiDB:YKL149C; VEuPathDB:YKL149C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: PRP26
Summary: Enables RNA lariat debranching enzyme activity. Involved in RNA metabolic process; pseudohyphal growth; and retrotransposition. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in brain disease. Orthologous to human DBR1 (debranching RNA lariats 1). [provided by Alliance of Genome Resources, Nov 2024]
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Chromosome XI - NC_001143.9 Genomic Context describing neighboring genes

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Saccharomyces cerevisiae RNA lariat debranching enzyme, Dbr1p, is required for completion of reverse transcription by the retrovirus-like element Ty1 and cleaves branched Ty1 RNAs.
Title: Saccharomyces cerevisiae RNA lariat debranching enzyme, Dbr1p, is required for completion of reverse transcription by the retrovirus-like element Ty1 and cleaves branched Ty1 RNAs.
Sequencing of lariat termini in S. cerevisiae reveals 5' splice sites, branch points, and novel splicing events.
Title: Sequencing of lariat termini in S. cerevisiae reveals 5' splice sites, branch points, and novel splicing events.
Dbr1p does not debranch an obligatory 2',5'-branched RNA linkage during the normal biological pathway of Ty1 retrotransposition.
Title: Ty1 reverse transcriptase does not read through the proposed 2',5'-branched retrotransposition intermediate in vitro.
data link three RNA catabolic enzymes, Rex4p, Rnt1p, and Dbr1p, to ITS1 processing and the relative production of 5.8SS and 5.8SL rRNA
Title: The RNA catabolic enzymes Rex4p, Rnt1p, and Dbr1p show genetic interaction with trans-acting factors involved in processing of ITS1 in Saccharomyces cerevisiae pre-rRNA.
Identification of 13 residues that are important for the intron debranching activity of Dbr1.
Title: Structure-function analysis of yeast RNA debranching enzyme (Dbr1), a manganese-dependent phosphodiesterase.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA lariat debranching enzyme activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA lariat debranching enzyme activity	IDA Inferred from Direct Assay more info	PubMed
enables RNA lariat debranching enzyme activity	IEA Inferred from Electronic Annotation more info
enables RNA lariat debranching enzyme activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on ester bonds	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in RNA catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA splicing, via spliceosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pseudohyphal growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retrotransposition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sno(s)RNA metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IC Inferred by Curator more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

NP_012773.1

RNA lariat debranching enzyme; catalyzes debranching of lariat introns formed during pre-mRNA splicing; required for efficient Ty1 transposition; knockdown of human homolog Dbr1 rescues toxicity of RNA-binding proteins TDP-43 and FUS which are implicated in amyotrophic lateral sclerosis (ALS), suggests potential therapeutic target for ALS and related TDP-43 proteinopathies; human homolog DBR1 can complement yeast dbr1 null mutant

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