U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

YJU2 mRNA splicing protein YJU2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853767, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
YJU2
Official Full Name
mRNA splicing protein YJU2
Primary source
SGD:S000001578
Locus tag
YKL095W
See related
AllianceGenome:SGD:S000001578; FungiDB:YKL095W; VEuPathDB:YKL095W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CWC16
Summary
Contributes to first spliceosomal transesterification activity. Involved in generation of catalytic spliceosome for first transesterification step. Located in nucleus. Part of U2-type catalytic step 1 spliceosome. Orthologous to human YJU2 (YJU2 splicing factor homolog). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See YJU2 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (262277..263113)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Cwp2p Neighboring gene Cwp1p Neighboring gene acylglycerol lipase Neighboring gene Mbr1p

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Sequence of the novel essential gene YJU2 and two flanking reading frames located within a 3.2 kb EcoRI fragment from chromosome X of Saccharomyces cerevisiae. Forrová H, et al. Yeast, 1992 May. PMID 1626433
  2. DEAH-box ATPase Prp16 has dual roles in remodeling of the spliceosome in catalytic steps. Tseng CK, et al. RNA, 2011 Jan. PMID 21098140, Free PMC Article
  3. Structure of a yeast step II catalytically activated spliceosome. Yan C, et al. Science, 2017 Jan 13. PMID 27980089
  4. A central role of Cwc25 in spliceosome dynamics during the catalytic phase of pre-mRNA splicing. Tseng CK, et al. RNA, 2017 Apr. PMID 28057857, Free PMC Article
  5. Structural basis for conformational equilibrium of the catalytic spliceosome. Wilkinson ME, et al. Mol Cell, 2021 Apr 1. PMID 33705709, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In the absence of the C domain, Yju2-N domain is not stably associated with the spliceosome after lariat formation, and thus bypasses the need for Prp16.
    Title: A weak spliceosome-binding domain of Yju2 functions in the first step and bypasses Prp16 in the second step of splicing.
  2. Cwc25 functions in the final step of the first catalytic reaction after the action of Prp2.
    Title: Cwc25 is a novel splicing factor required after Prp2 and Yju2 to facilitate the first catalytic reaction.
  3. Ntc90 is required for recruiting first step factor Yju2.
    Title: Ntc90 is required for recruiting first step factor Yju2 but not for spliceosome activation.
  4. Yju2 acts in concert with an unidentified heat-resistant factor(s) in an ATP-independent manner to promote the first catalytic reaction of pre-mRNA splicing after Prp2-mediated structural rearrangement of the spliceosome.
    Title: A novel splicing factor, Yju2, is associated with NTC and acts after Prp2 in promoting the first catalytic reaction of pre-mRNA splicing.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to first spliceosomal transesterification activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in generation of catalytic spliceosome for first transesterification step IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in generation of catalytic spliceosome for first transesterification step IEA
Inferred from Electronic Annotation
more info
  
involved_in generation of catalytic spliceosome for second transesterification step IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of U2-type catalytic step 1 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U2-type catalytic step 1 spliceosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of U2-type catalytic step 1 spliceosome IEA
Inferred from Electronic Annotation
more info
  
part_of U2-type catalytic step 2 spliceosome IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
mRNA splicing protein YJU2
NP_012828.1
  • Essential protein required for pre-mRNA splicing; associates transiently with the spliceosomal NTC ('nineteen complex') and acts after Prp2p to promote the first catalytic reaction of splicing

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    262277..263113
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179661.1 → NP_012828.1  TPA: mRNA splicing protein YJU2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012828.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXJ3, P28320
    UniProtKB/TrEMBL
    A6ZZM2, B3LQZ9, B5VM63, C7GVL5, C8ZC80, G2WHT8, N1P285
    Conserved Domains (1) summary
    COG5134
    Location:7 → 278
    COG5134; Uncharacterized conserved protein [Function unknown]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P28320.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools