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BUD2 GTPase-activating protein BUD2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853770, updated on 2-Nov-2024

Summary

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Official Symbol
BUD2
Official Full Name
GTPase-activating protein BUD2
Primary source
SGD:S000001575
Locus tag
YKL092C
See related
AllianceGenome:SGD:S000001575; FungiDB:YKL092C; VEuPathDB:YKL092C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CLA2; ERC25
Summary
Enables GTPase activator activity. Involved in cellular bud site selection; invasive growth in response to glucose limitation; and mitotic spindle orientation checkpoint signaling. Located in cellular bud neck and incipient cellular bud site. Human ortholog(s) of this gene implicated in artery disease (multiple); autosomal dominant intellectual developmental disorder 5; lung cancer; prostate cancer; and stomach cancer. Orthologous to several human genes including DAB2IP (DAB2 interacting protein); RASAL2 (RAS protein activator like 2); and RASAL3 (RAS protein activator like 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See BUD2 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (266145..269459, complement)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene acylglycerol lipase Neighboring gene Mbr1p Neighboring gene phosphatidylinositol/phosphatidylcholine-binding protein Neighboring gene Cue2p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The morphology of Saccharomyces cerevisiae colonies is affected by cell adhesion and the budding pattern. Vopálenská I, et al. Res Microbiol, 2005 Nov. PMID 16081250
  2. Localization of Bud2p, a GTPase-activating protein necessary for programming cell polarity in yeast to the presumptive bud site. Park HO, et al. Genes Dev, 1999 Aug 1. PMID 10444589, Free PMC Article
  3. A localized GTPase exchange factor, Bud5, determines the orientation of division axes in yeast. Marston AL, et al. Curr Biol, 2001 May 15. PMID 11378394
  4. A novel role for the GTPase-activating protein Bud2 in the spindle position checkpoint. Nelson SA, et al. PLoS One, 2012. PMID 22558355, Free PMC Article
  5. BUD2 encodes a GTPase-activating protein for Bud1/Rsr1 necessary for proper bud-site selection in yeast. Park HO, et al. Nature, 1993 Sep 16. PMID 8371782

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in axial cellular bud site selection IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in bipolar cellular bud site selection IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment or maintenance of cell polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in filamentous growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in invasive filamentous growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in invasive growth in response to glucose limitation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic spindle orientation checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cellular bud neck HDA PubMed 
located_in cellular bud neck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm HDA PubMed 
located_in incipient cellular bud site IDA
Inferred from Direct Assay
more info
 PubMed 
located_in prospore membrane HDA PubMed 

General protein information

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Preferred Names
GTPase-activating protein BUD2
NP_012831.1
  • GTPase activating factor for Rsr1p/Bud1p; plays a role in spindle position checkpoint distinct from its role in bud site selection; required for both axial and bipolar budding patterns; mutants exhibit random budding in all cell types; contains two PH-like domains

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    266145..269459 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179658.1 → NP_012831.1  TPA: GTPase-activating protein BUD2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012831.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXJ6, P33314
    UniProtKB/TrEMBL
    A6ZZM5, G2WHU1, N1P7R7
    Conserved Domains (2) summary
    cd00030
    Location:337 → 444
    C2; C2 domain
    cd05137
    Location:460 → 819
    RasGAP_CLA2_BUD2; Ras-GTPase Activating Domain of CLA2/BUD2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P33314.2

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