CAB3 phosphopantothenoylcysteine decarboxylase complex subunit CAB3 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: CAB3
Official Full Name: phosphopantothenoylcysteine decarboxylase complex subunit CAB3
Primary source: SGD:S000001571
Locus tag: YKL088W
See related: AllianceGenome:SGD:S000001571; FungiDB:YKL088W; VEuPathDB:YKL088W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Contributes to phosphopantothenoylcysteine decarboxylase activity. Involved in coenzyme A biosynthetic process. Located in cytoplasm. Part of CoA-synthesizing protein complex and phosphopantothenoylcysteine decarboxylase complex. Used to study dilated cardiomyopathy. Orthologous to human PPCDC (phosphopantothenoylcysteine decarboxylase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See CAB3 in Genome Data Viewer

Location:: chromosome: XI

Exon count:: 1

Sequence:: Chromosome: XI; NC_001143.9 (275283..276998)

Chromosome XI - NC_001143.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results show that Cab2, Cab3, Cab4, and Cab5 indeed bind to each other, with Cab3 as the sole protein, which can interact with itself and other Cab proteins.
Title: Molecular characterization of the heteromeric coenzyme A-synthesizing protein complex (CoA-SPC) in the yeast Saccharomyces cerevisiae.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables FMN binding	IBA Inferred from Biological aspect of Ancestor more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
contributes_to phosphopantothenoylcysteine decarboxylase activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to phosphopantothenoylcysteine decarboxylase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in coenzyme A biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in coenzyme A biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in coenzyme A biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of CoA-synthesizing protein complex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of phosphopantothenoylcysteine decarboxylase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of phosphopantothenoylcysteine decarboxylase complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: phosphopantothenoylcysteine decarboxylase complex subunit CAB3

NP_012835.1

Subunit of PPCDC and CoA-SPC complexes involved in CoA biosynthesis; subunits of the phosphopantothenoylcysteine decarboxylase (PPCDC) complex are: Cab3p, Sis2p, Vhs3p, while the subunits of the CoA-synthesizing protein complex (CoA-SPC) are: Cab2p, Cab3p, Cab4p, and Cab5p as well as Sis2p and Vhs3p; null mutant lethality is complemented by E. coli coaBC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001143.9 Reference assembly

Range

275283..276998

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179654.1 → NP_012835.1 TPA: phosphopantothenoylcysteine decarboxylase complex subunit CAB3 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012835.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VXK0, P36076

UniProtKB/TrEMBL

B3LR04, G2WHU5, N1P7S0

Conserved Domains (2) summary

COG0452
Location:23 → 514

CoaBC; Phosphopantothenoylcysteine synthetase/decarboxylase [Coenzyme transport and metabolism]

cl19190
Location:264 → 497

Flavoprotein