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RRP14 ribosome biosynthesis protein RRP14 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853780, updated on 9-Dec-2024

Summary

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Official Symbol
RRP14
Official Full Name
ribosome biosynthesis protein RRP14
Primary source
SGD:S000001565
Locus tag
YKL082C
See related
AllianceGenome:SGD:S000001565; FungiDB:YKL082C; VEuPathDB:YKL082C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable DNA binding activity and RNA binding activity. Involved in ribosomal large subunit biogenesis and ribosomal small subunit biogenesis. Located in nucleolus. Orthologous to human SURF6 (surfeit 6). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See RRP14 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (281025..282329, complement)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene malate dehydrogenase MDH1 Neighboring gene Hot13p Neighboring gene translation elongation factor EF1B gamma Neighboring gene ncRNA Neighboring gene H(+)-transporting V1 sector ATPase subunit C

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Yeast Rrp14p is required for ribosomal subunit synthesis and for correct positioning of the mitotic spindle during mitosis. Oeffinger M, et al. Nucleic Acids Res, 2007. PMID 17272295, Free PMC Article
  2. Identification of an evolutionary conserved SURF-6 domain in a family of nucleolar proteins extending from human to yeast. Polzikov M, et al. Biochem Biophys Res Commun, 2005 Feb 4. PMID 15629442
  3. Yeast Rrp14p is a nucleolar protein involved in both ribosome biogenesis and cell polarity. Yamada H, et al. RNA, 2007 Nov. PMID 17804645, Free PMC Article
  4. Evolutionarily conserved function of RRP36 in early cleavages of the pre-rRNA and production of the 40S ribosomal subunit. Gérus M, et al. Mol Cell Biol, 2010 Mar. PMID 20038530, Free PMC Article
  5. Ebp2 and Brx1 function cooperatively in 60S ribosomal subunit assembly in Saccharomyces cerevisiae. Shimoji K, et al. Nucleic Acids Res, 2012 May. PMID 22319211, Free PMC Article

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results suggest that Rrp14p has dual functions in ribosome synthesis and polarized cell growth.
    Title: Yeast Rrp14p is a nucleolar protein involved in both ribosome biogenesis and cell polarity.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosomal large subunit biogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosomal large subunit biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosomal small subunit biogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosomal small subunit biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ribosome biosynthesis protein RRP14
NP_012841.1
  • Essential protein, constituent of 66S pre-ribosomal particles; interacts with proteins involved in ribosomal biogenesis and cell polarity; member of the SURF-6 family

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    281025..282329 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179648.1 → NP_012841.1  TPA: ribosome biosynthesis protein RRP14 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012841.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXK5, P36080
    UniProtKB/TrEMBL
    A6ZZN5, B5VM74, C7GVM6, C8ZC91, G2WHV0, N1P0J0
    Conserved Domains (2) summary
    pfam04935
    Location:221 → 400
    SURF6; Surfeit locus protein 6
    pfam15459
    Location:8 → 58
    RRP14; 60S ribosome biogenesis protein Rrp14
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P36080.1

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