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MDM35 Mdm35p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853812, updated on 29-Jun-2024

Summary

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Gene symbol
MDM35
Gene description
Mdm35p
Primary source
FungiDB:YKL053C-A
Locus tag
YKL053C-A
See related
SGD:S000007243; AllianceGenome:SGD:S000007243; VEuPathDB:YKL053C-A
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in mitochondrial respiratory chain complex assembly and phospholipid translocation. Located in mitochondrial intermembrane space. Used to study breast cancer. Orthologous to human TRIAP1 (TP53 regulated inhibitor of apoptosis 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See MDM35 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (339182..339442, complement)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) Neighboring gene DNA damage-responsive RNA polymerase-degradation factor DEF1 Neighboring gene Ask1p Neighboring gene Sfk1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular mechanism of mitochondrial phosphatidate transfer by Ups1. Lu J, et al. Commun Biol, 2020 Aug 25. PMID 32843686, Free PMC Article
  2. Structural basis of intramitochondrial phosphatidic acid transport mediated by Ups1-Mdm35 complex. Yu F, et al. EMBO Rep, 2015 Jul. PMID 26071601, Free PMC Article
  3. Apoptosis inhibitor TRIAP1 is a novel effector of drug resistance. Adams C, et al. Oncol Rep, 2015 Jul. PMID 25998939
  4. Phosphatidylserine transport by Ups2-Mdm35 in respiration-active mitochondria. Miyata N, et al. J Cell Biol, 2016 Jul 4. PMID 27354379, Free PMC Article
  5. Structural and mechanistic insights into phospholipid transfer by Ups1-Mdm35 in mitochondria. Watanabe Y, et al. Nat Commun, 2015 Aug 3. PMID 26235513, Free PMC Article

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. crystal structure of Ups1-Mdm35 bound with a phosphatidic acid (PA) molecule at 2.0 A resolution; study reveals molecular basis of Ups1-Mdm35-mediated PA binding and transfer and sheds new light on mechanism of intramitochondrial lipid transport by MSF1/PRELI family proteins
    Title: Structural basis of intramitochondrial phosphatidic acid transport mediated by Ups1-Mdm35 complex.
  2. The Ups1-Mdm35 complex constitutes a single domain that has a deep pocket and flexible Omega-loop lid. A basic residue at the pocket bottom and the Omega-loop lid are important for phosphatidic acid extraction from the membrane following Ups1 binding.
    Title: Structural and mechanistic insights into phospholipid transfer by Ups1-Mdm35 in mitochondria.
  3. The authors show that Ups1, Ups2 and Ups3 protein import is mediated by another mitochondrial intermembrane space protein, Mdm35p.
    Title: Mdm35p imports Ups proteins into the mitochondrial intermembrane space by functional complex formation.
  4. The authors identified Mdm35, a member of the twin Cx9C protein family, as a novel interaction partner of Ups1 and Ups2.
    Title: Regulation of mitochondrial phospholipids by Ups1/PRELI-like proteins depends on proteolysis and Mdm35.
  5. Loss of Mdm35, Emi1, and Mrp10 leads to abnormal mitochondrial morphology
    Title: Systematic analysis of the twin cx(9)c protein family.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
contributes_to phosphatidic acid transfer activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in intermembrane lipid transfer IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial respiratory chain complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phospholipid translocation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid translocation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phospholipid transport IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial intermembrane space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial intermembrane space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial intermembrane space IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Mdm35p
NP_012870.1
  • Mitochondrial intermembrane space protein; forms complex with Ups2p that transfers phosphatidylserine from outer membrane to inner membrane for phosphatidylethanolamine synthesis; mutation affects mitochondrial distribution and morphology; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    339182..339442 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184336.1 → NP_012870.1  TPA: Mdm35p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012870.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXN4, O60200, Q6Q599
    UniProtKB/TrEMBL
    A0A6A5PWC8, A6ZZR3, B3LR37, C7GP21, C8ZCB8, G2WHX9, N1P099
    Conserved Domains (1) summary
    pfam05254
    Location:7 → 75
    UPF0203; Uncharacterized protein family (UPF0203)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O60200.3

Gene LinkOut

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