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TTI1 Tti1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853834, updated on 2-Nov-2024

Summary

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Official Symbol
TTI1
Official Full Name
Tti1p
Primary source
SGD:S000001516
Locus tag
YKL033W
See related
AllianceGenome:SGD:S000001516; FungiDB:YKL033W; VEuPathDB:YKL033W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to be involved in chromatin organization. Located in mitochondrion. Used to study cancer. Orthologous to human TTI1 (TELO2 interacting protein 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See TTI1 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (375456..378572)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene ubiquitin-protein ligase TUL1 Neighboring gene putative hydrolase Neighboring gene tRNA-Val Neighboring gene DNA-binding transcription repressor IXR1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Essentiality of Sis1, a J-domain protein Hsp70 cochaperone, can be overcome by Tti1, a specialized PIKK chaperone. Schilke BA, et al. Mol Biol Cell, 2022 Mar 1. PMID 34935410, Free PMC Article
  2. Saccharomyces cerevisiae Tel2 plays roles in TORC signaling and telomere maintenance that can be mutationally separated. Rozario D, et al. Biochem Biophys Res Commun, 2012 Jan 27. PMID 22227188
  3. Functional Diversity of Haloacid Dehalogenase Superfamily Phosphatases from Saccharomyces cerevisiae: BIOCHEMICAL, STRUCTURAL, AND EVOLUTIONARY INSIGHTS. Kuznetsova E, et al. J Biol Chem, 2015 Jul 24. PMID 26071590, Free PMC Article
  4. Identification of the novel TRAPP associated protein Tca17. Montpetit B, et al. Traffic, 2009 Jun. PMID 19220810
  5. Mass-murdering: deletion of twenty-three ORFs from Saccharomyces cerevisiae chromosome XI reveals five genes essential for growth and three genes conferring detectable mutant phenotype. Wysocki R, et al. Gene, 1999 Mar 18. PMID 10095102

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Essentiality of Sis1, a J-domain protein Hsp70 cochaperone, can be overcome by Tti1, a specialized PIKK chaperone.
    Title: Essentiality of Sis1, a J-domain protein Hsp70 cochaperone, can be overcome by Tti1, a specialized PIKK chaperone.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Tti1p
NP_012892.1
  • Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1; similar to S. pombe Tti1p; detected in highly purified mitochondria in high-throughput studies

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    375456..378572
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179599.1 → NP_012892.1  TPA: Tti1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012892.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXQ3, P36097
    UniProtKB/TrEMBL
    B5VMC1, G2WHZ8, N1P0B6
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P36097.1

Gene LinkOut

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