TFA1 transcription factor TFIIE subunit TFA1 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: TFA1
Official Full Name: transcription factor TFIIE subunit TFA1
Primary source: SGD:S000001511
Locus tag: YKL028W
See related: AllianceGenome:SGD:S000001511; FungiDB:YKL028W; VEuPathDB:YKL028W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Contributes to RNA polymerase II complex binding activity; TFIIH-class transcription factor complex binding activity; and single-stranded DNA binding activity. Involved in transcription open complex formation at RNA polymerase II promoter. Located in mitochondrion. Part of transcription factor TFIIE complex and transcription preinitiation complex. Orthologous to human GTF2E1 (general transcription factor IIE subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome XI - NC_001143.9 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
contributes_to RNA polymerase II complex binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II complex binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to TFIIH-class transcription factor complex binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
contributes_to single-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcription initiation at RNA polymerase II promoter	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcription initiation at RNA polymerase II promoter	IEA Inferred from Electronic Annotation more info
involved_in transcription open complex formation at RNA polymerase II promoter	IDA Inferred from Direct Assay more info	PubMed
involved_in transcription open complex formation at RNA polymerase II promoter	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrion	HDA more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription factor TFIIE complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription factor TFIIE complex	IDA Inferred from Direct Assay more info	PubMed
part_of transcription preinitiation complex	IDA Inferred from Direct Assay more info	PubMed

NP_012897.3

TFIIE large subunit; involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening

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