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MAK11 Mak11p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853847, updated on 18-Sep-2024

Summary

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Official Symbol
MAK11
Official Full Name
Mak11p
Primary source
SGD:S000001504
Locus tag
YKL021C
See related
AllianceGenome:SGD:S000001504; FungiDB:YKL021C; VEuPathDB:YKL021C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); and ribosomal large subunit assembly. Located in membrane. Orthologous to human PAK1IP1 (PAK1 interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See MAK11 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (397344..398750, complement)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Ska1p Neighboring gene anaphase promoting complex subunit CDC16 Neighboring gene Spt23p Neighboring gene bifunctional protein farnesyltransferase/protein geranylgeranyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The MAK11 protein is essential for cell growth and replication of M double-stranded RNA and is apparently a membrane-associated protein. Icho T, et al. J Biol Chem, 1988 Jan 25. PMID 2826479
  2. Mak mutants of yeast: mapping and characterization. Wickner RB, et al. J Bacteriol, 1979 Oct. PMID 387719, Free PMC Article
  3. Molecular characterization of chromosomal genes affecting double-stranded RNA replication in Saccharomyces cerevisiae. Icho T, et al. Basic Life Sci, 1986. PMID 3551912
  4. Yeast virus propagation depends critically on free 60S ribosomal subunit concentration. Ohtake Y, et al. Mol Cell Biol, 1995 May. PMID 7739558, Free PMC Article
  5. 60S ribosomal subunit assembly dynamics defined by semi-quantitative mass spectrometry of purified complexes. Lebreton A, et al. Nucleic Acids Res, 2008 Sep. PMID 18658244, Free PMC Article

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables protein kinase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosomal large subunit assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in ribosomal large subunit assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosomal large subunit assembly IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in ribosomal large subunit biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Mak11p
NP_012904.3
  • Protein involved in an early step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    397344..398750 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179587.3 → NP_012904.3  TPA: Mak11p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012904.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    A6ZZU3, B3LR63, B5VMD2, G2WI09, N1NZA9
    Conserved Domains (2) summary
    sd00039
    Location:109 → 144
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:98 → 384
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
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