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CCE1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853858, updated on 22-Aug-2024

Summary

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Official Symbol
CCE1
Primary source
FungiDB:YKL011C
Locus tag
YKL011C
See related
SGD:S000001494; AllianceGenome:SGD:S000001494; VEuPathDB:YKL011C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
MGT1
Summary
Enables endodeoxyribonuclease activity. Involved in mitochondrial genome maintenance. Located in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (420155..421216, complement)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Arc19p Neighboring gene Prp40p Neighboring gene putative ubiquitin-protein ligase UFD4 Neighboring gene Mrt4p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The yeast Holliday junction resolvase, CCE1, can restore wild-type mitochondrial DNA to human cells carrying rearranged mitochondrial DNA. Sembongi H, et al. Hum Mol Genet, 2007 Oct 1. PMID 17666405
  2. The role of the SAP motif in promoting Holliday junction binding and resolution by SpCCE1. Ahn JS, et al. J Biol Chem, 2003 Aug 1. PMID 12748193
  3. Yeast resolving enzyme CCE1 makes sequential cleavages in DNA junctions within the lifetime of the complex. Fogg JM, et al. Biochemistry, 2000 Apr 11. PMID 10747798
  4. Extensive central disruption of a four-way junction on binding CCE1 resolving enzyme. Déclais AC, et al. J Mol Biol, 2000 Feb 18. PMID 10669598
  5. Quantitation of metal ion and DNA junction binding to the Holliday junction endonuclease Cce1. Kvaratskhelia M, et al. Biochemistry, 1999 Dec 14. PMID 10600123

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Abf2p does not significantly affect either binding of Cce1p to branched DNA or rate and specificity of Holliday junction resolution. These data suggest the existence of an alternative homologous recombination pathway in yeast mitochondria.
    Title: Interaction between Saccharomyces cerevisiae Mitochondrial DNA-Binding Protein Abf2p and Cce1p Resolvase.
  2. Results show that CCE1 can mediate intramolecular recombination in human mitochondria, and it is necessary to strictly regulate the expression of CCE1 in human cells to ensure the selection and maintenance of WT mtDNA.
    Title: The yeast Holliday junction resolvase, CCE1, can restore wild-type mitochondrial DNA to human cells carrying rearranged mitochondrial DNA.
  3. The putative recombination genes CCE1, DIN7, and MHR1 have overlapping function with the mismatch repair homolog MSH1 in point mutation avoidance and suppression of aberrant recombination events.
    Title: Overlapping contributions of Msh1p and putative recombination proteins Cce1p, Din7p, and Mhr1p in large-scale recombination and genome sorting events in the mitochondrial genome of Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA endonuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables Y-form DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables crossed form four-way junction DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables flap-structured DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial genome maintenance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial genome maintenance IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cruciform cutting endonuclease
NP_012914.1
  • Mitochondrial cruciform cutting endonuclease; cleaves Holliday junctions formed during recombination of mitochondrial DNA; CCE1 has a paralog, MRS1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    420155..421216 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179577.1 → NP_012914.1  TPA: cruciform cutting endonuclease [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012914.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXS5, Q03702
    UniProtKB/TrEMBL
    A6ZZV4, B3LR73, C7GRH0, G2WI20, N1P0R6
    Conserved Domains (1) summary
    cd16963
    Location:22 → 318
    CCE1; fungal mitochondrial Holliday junction resolvases similar to Saccharomyces cerevisiae CCE1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03702.1

Gene LinkOut

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