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CAP1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853862, updated on 22-Aug-2024

Summary

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Official Symbol
CAP1
Primary source
FungiDB:YKL007W
Locus tag
YKL007W
See related
SGD:S000001490; AllianceGenome:SGD:S000001490; VEuPathDB:YKL007W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables actin filament binding activity. Involved in barbed-end actin filament capping. Located in actin cortical patch and cellular bud tip. Part of F-actin capping protein complex and incipient cellular bud site. Orthologous to several human genes including CAPZA1 (capping actin protein of muscle Z-line subunit alpha 1) and CAPZA2 (capping actin protein of muscle Z-line subunit alpha 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (429302..430108)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Mrt4p Neighboring gene sphingosine N-acyltransferase LAC1 Neighboring gene Sft1p Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sequence of a 7.8 kb segment on the left arm of yeast chromosome XI reveals four open reading frames, including the CAP1 gene, an intron-containing gene and a gene encoding a homolog to the mammalian UOG-1 gene. Boyer J, et al. Yeast, 1993 Mar. PMID 8488728
  2. Capping protein binding to actin in yeast: biochemical mechanism and physiological relevance. Kim K, et al. J Cell Biol, 2004 Feb 16. PMID 14769858, Free PMC Article
  3. Effects of null mutations and overexpression of capping protein on morphogenesis, actin distribution and polarized secretion in yeast. Amatruda JF, et al. J Cell Biol, 1992 Dec. PMID 1447293, Free PMC Article
  4. Purification, characterization, and immunofluorescence localization of Saccharomyces cerevisiae capping protein. Amatruda JF, et al. J Cell Biol, 1992 Jun. PMID 1315784, Free PMC Article
  5. AP1-mediated multidrug resistance in Saccharomyces cerevisiae requires FLR1 encoding a transporter of the major facilitator superfamily. Alarco AM, et al. J Biol Chem, 1997 Aug 1. PMID 9235926

See all (78) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The structural basis of actin monomer re-charging by CAP1 protein has been reported.
    Title: Structural basis of actin monomer re-charging by cyclase-associated protein.
  2. a novel model for how sequential interactions between actin monomers, twinfilin, CP, and actin filaments promote cytoskeletal dynamics
    Title: Biological role and structural mechanism of twinfilin-capping protein interaction.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament capping IEA
Inferred from Electronic Annotation
more info
  
involved_in barbed-end actin filament capping IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in barbed-end actin filament capping IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in barbed-end actin filament capping IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of F-actin capping protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of F-actin capping protein complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of F-actin capping protein complex IEA
Inferred from Electronic Annotation
more info
  
part_of F-actin capping protein complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in actin cortical patch IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in actin cortical patch IDA
Inferred from Direct Assay
more info
 PubMed 
located_in actin cortical patch IEA
Inferred from Electronic Annotation
more info
  
located_in actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cellular bud neck HDA PubMed 
located_in cellular bud tip HDA PubMed 
located_in cellular bud tip IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cortical cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in incipient cellular bud site IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mating projection tip HDA PubMed 
located_in mitotic actomyosin contractile ring IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane HDA PubMed 
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Cap1p
NP_012918.1
  • Alpha subunit of the capping protein heterodimer (Cap1p and Cap2p); capping protein (CP) binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches; protein increases in abundance and relocalizes from bud neck to plasma membrane upon DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    429302..430108
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179573.1 → NP_012918.1  TPA: Cap1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012918.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXS9, P28495
    UniProtKB/TrEMBL
    A6ZZV8, B3LR77, B5VME6, C7GRG6, C8ZCF9, G2WI24, N1P803
    Conserved Domains (1) summary
    pfam01267
    Location:10 → 265
    F-actin_cap_A; F-actin capping protein alpha subunit
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P28495.1

Gene LinkOut

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