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BYE1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853865, updated on 22-Aug-2024

Summary

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Official Symbol
BYE1
Primary source
FungiDB:YKL005C
Locus tag
YKL005C
See related
SGD:S000001488; AllianceGenome:SGD:S000001488; VEuPathDB:YKL005C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables chromatin binding activity and methylated histone binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human DIDO1 (death inducer-obliterator 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (433093..434877, complement)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ribosomal 60S subunit protein L14A Neighboring gene inositol phosphorylceramide synthase Neighboring gene mitochondrial 37S ribosomal protein YmS16

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. PHD and TFIIS-Like domains of the Bye1 transcription factor determine its multivalent genomic distribution. Pinskaya M, et al. PLoS One, 2014. PMID 25029256, Free PMC Article
  2. The ESS1 prolyl isomerase and its suppressor BYE1 interact with RNA pol II to inhibit transcription elongation in Saccharomyces cerevisiae. Wu X, et al. Genetics, 2003 Dec. PMID 14704159, Free PMC Article
  3. Structures of RNA polymerase II complexes with Bye1, a chromatin-binding PHF3/DIDO homologue. Kinkelin K, et al. Proc Natl Acad Sci U S A, 2013 Sep 17. PMID 24003114, Free PMC Article
  4. The PHD finger: implications for chromatin-mediated transcriptional regulation. Aasland R, et al. Trends Biochem Sci, 1995 Feb. PMID 7701562
  5. The Ess1 prolyl isomerase is linked to chromatin remodeling complexes and the general transcription machinery. Wu X, et al. EMBO J, 2000 Jul 17. PMID 10899126, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Once Pol II is engaged into elongation, Bye1 binds directly to the transcriptional machinery, modulating its progression along the gene.
    Title: PHD and TFIIS-Like domains of the Bye1 transcription factor determine its multivalent genomic distribution.
  2. Bye1 is a chromatin transcription factor that links histones with active posttranslational modifications to transcribing Pol II.
    Title: Structures of RNA polymerase II complexes with Bye1, a chromatin-binding PHF3/DIDO homologue.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables methylated histone binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IC
Inferred by Curator
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Bye1p
NP_012921.3
  • Negative regulator of transcription elongation; contains a TFIIS-like domain that associates with chromatin and a PHD domain that interacts with H3K4me3; multicopy suppressor of temperature-sensitive ess1 mutations, binds RNA polymerase II large subunit

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    433093..434877 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179571.3 → NP_012921.3  TPA: Bye1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012921.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6ZZW1, D6VXT2, P36106
    UniProtKB/TrEMBL
    G2WI27, N1P807
    Conserved Domains (3) summary
    smart00510
    Location:235 → 354
    TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
    cd15570
    Location:74 → 131
    PHD_Bye1p_SIZ1_like; PHD domain found in Saccharomyces cerevisiae bypass of ESS1 protein 1 (Bye1p), the E3 Sumo Ligase SIZ1, and similar proteins
    pfam07744
    Location:434 → 589
    SPOC; SPOC domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P36106.1

Gene LinkOut

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