PAP1 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: PAP1
Primary source: FungiDB:YKR002W
Locus tag: YKR002W
See related: SGD:S000001710; AllianceGenome:SGD:S000001710; VEuPathDB:YKR002W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables polynucleotide adenylyltransferase activity. Involved in mRNA polyadenylation and sno(s)RNA polyadenylation. Part of mRNA cleavage and polyadenylation specificity factor complex. Orthologous to several human genes including PAPOLA (poly(A) polymerase alpha). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome XI - NC_001143.9 Genomic Context describing neighboring genes

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results suggest a novel mechanism for controlling Pap1 activity, and possible models invoking these newly-discovered interactions are discussed.
Title: Novel interactions at the essential N-terminus of poly(A) polymerase that could regulate poly(A) addition in Saccharomyces cerevisiae.
TFIIB interaction with the CF1 complex and Pap1 is crucial for gene looping and transcriptional regulation.
Title: Evidence for a complex of transcription factor IIB with poly(A) polymerase and cleavage factor 1 subunits required for gene looping.
in the absence of Pap1, Fip1 is largely, if not completely, unfolded
Title: Structure of yeast poly(A) polymerase in complex with a peptide from Fip1, an intrinsically disordered protein.
new poly(A) polymerase complex that contains Air1p or Air2p as potential RNA-binding subunits
Title: A new yeast poly(A) polymerase complex involved in RNA quality control.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables poly(A) RNA polymerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables poly(A) RNA polymerase activity	IDA Inferred from Direct Assay more info	PubMed
enables poly(A) RNA polymerase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA 3'-end processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA 3'-end processing	IDA Inferred from Direct Assay more info	PubMed
involved_in mRNA 3'-end processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in sno(s)RNA 3'-end processing	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of mRNA cleavage and polyadenylation specificity factor complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

NP_012927.3

Poly(A) polymerase; one of three factors required for mRNA 3'-end polyadenylation, forms multiprotein complex with polyadenylation factor I (PF I), also required for mRNA nuclear export; may also polyadenylate rRNAs; required for gene looping

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The following sections contain reference sequences that belong to a specific genome build. Explain