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IRS4 Irs4p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853889, updated on 28-Oct-2024

Summary

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Official Symbol
IRS4
Official Full Name
Irs4p
Primary source
SGD:S000001727
Locus tag
YKR019C
See related
AllianceGenome:SGD:S000001727; FungiDB:YKR019C; VEuPathDB:YKR019C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in autophagy; fungal-type cell wall organization; and rDNA heterochromatin formation. Located in phagophore assembly site. Orthologous to several human genes including EHD1 (EH domain containing 1); EHD2 (EH domain containing 2); and EHD3 (EH domain containing 3). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See IRS4 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (476216..478063, complement)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene E3 ubiquitin-protein ligase HEL1 Neighboring gene uncharacterized protein Neighboring gene Vps51p Neighboring gene Aly1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Recognition specificity of individual EH domains of mammals and yeast. Paoluzi S, et al. EMBO J, 1998 Nov 16. PMID 9822599, Free PMC Article
  2. Irs4p and Tax4p: two redundant EH domain proteins involved in autophagy. Bugnicourt A, et al. Traffic, 2008 May. PMID 18298591
  3. Siz2 Prevents Ribosomal DNA Recombination by Modulating Levels of Tof2 in Saccharomyces cerevisiae. Abraham NM, et al. mSphere, 2019 Nov 27. PMID 31776241, Free PMC Article
  4. Negative regulation of phosphatidylinositol 4,5-bisphosphate levels by the INP51-associated proteins TAX4 and IRS4. Morales-Johansson H, et al. J Biol Chem, 2004 Sep 17. PMID 15265867
  5. Role for perinuclear chromosome tethering in maintenance of genome stability. Mekhail K, et al. Nature, 2008 Dec 4. PMID 18997772, Free PMC Article

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in autophagy IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endosomal transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fungal-type cell wall organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in rDNA heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion HDA PubMed 
located_in phagophore assembly site IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Irs4p
NP_012944.3
  • EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    476216..478063 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179809.3 → NP_012944.3  TPA: Irs4p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012944.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6ZZY3, D6VX84, P36115
    UniProtKB/TrEMBL
    G2WI50, N1NZF9
    Conserved Domains (1) summary
    cl27812
    Location:498 → 570
    EF-hand_4; Cytoskeletal-regulatory complex EF hand
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P36115.1

Gene LinkOut

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