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TRM2 tRNA (uracil(54)-C(5))-methyltransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 853930, updated on 2-Nov-2024

Summary

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Official Symbol
TRM2
Official Full Name
tRNA (uracil(54)-C(5))-methyltransferase
Primary source
SGD:S000001764
Locus tag
YKR056W
See related
AllianceGenome:SGD:S000001764; FungiDB:YKR056W; VEuPathDB:YKR056W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
NUC2; NUD1; RNC1
Summary
Enables double-stranded DNA 5'-3' DNA exonuclease activity; single-stranded DNA endodeoxyribonuclease activity; and tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent. Involved in tRNA modification. Orthologous to human TRMT2A (tRNA methyltransferase 2 homolog A) and TRMT2B (tRNA methyltransferase 2 homolog B). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See TRM2 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (549448..551367)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene dynein heavy chain Neighboring gene Rho family GTPase RHO4 Neighboring gene ribosomal 40S subunit protein S21A Neighboring gene glycogenin glucosyltransferase GLG1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Yeast RNC1 encodes a chimeric protein, RhoNUC, with a human rho motif and deoxyribonuclease activity. Chow TY, et al. Nucleic Acids Res, 1992 Oct 11. PMID 1408836, Free PMC Article
  2. Dual function of the tRNA(m(5)U54)methyltransferase in tRNA maturation. Johansson MJ, et al. RNA, 2002 Mar. PMID 12003492, Free PMC Article
  3. Defects in modification of cytoplasmic and mitochondrial transfer RNAs are caused by single nuclear mutations. Hopper AK, et al. Cell, 1982 Mar. PMID 7074684
  4. Identification of the TRM2 gene encoding the tRNA(m5U54)methyltransferase of Saccharomyces cerevisiae. Nordlund ME, et al. RNA, 2000 Jun. PMID 10864043, Free PMC Article
  5. In-vitro recombination in rad and rnc mutants of Saccharomyces cerevisiae. Moore PD, et al. Curr Genet, 1993 Jan. PMID 8428378

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A defective processing in absence of TRM2, with a synergistic effect of TRM2, and EXO1 in such DNA repair processing.
    Title: Synergistic effect of TRM2/RNC1 and EXO1 in DNA double-strand break repair in Saccharomyces cerevisiae.
  2. These results propose an important role for TRM2 in DNA repair with a potential involvement of its nuclease function in homologous recombination based repair of DNA double strand break.
    Title: Functional and genetic analysis of the Saccharomyces cerevisiae RNC1/TRM2: evidences for its involvement in DNA double-strand break repair.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables S-adenosylmethionine-dependent methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables double-stranded DNA 5'-3' DNA exonuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded DNA endodeoxyribonuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent IDA
Inferred from Direct Assay
more info
 PubMed 
enables tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent IEA
Inferred from Electronic Annotation
more info
  
enables tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in RNA modification IEA
Inferred from Electronic Annotation
more info
  
involved_in RNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA modification IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
tRNA (uracil(54)-C(5))-methyltransferase
NP_012982.2
  • tRNA methyltransferase; 5-methylates the uridine residue at position 54 of tRNAs and may also have a role in tRNA stabilization or maturation; involved in the methylation of guanosine and uridine ribonucleosides in mRNA; endo-exonuclease with a role in DNA repair

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    549448..551367
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179846.1 → NP_012982.2  TPA: tRNA (uracil(54)-C(5))-methyltransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012982.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXB7, P33753, Q86ZR6, Q9HGQ5
    UniProtKB/TrEMBL
    B5VMK5
    Conserved Domains (1) summary
    COG2265
    Location:166 → 632
    TrmA; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P33753.2

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