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MET1 uroporphyrinogen-III C-methyltransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 853943, updated on 2-Nov-2024

Summary

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Official Symbol
MET1
Official Full Name
uroporphyrinogen-III C-methyltransferase
Primary source
SGD:S000001777
Locus tag
YKR069W
See related
AllianceGenome:SGD:S000001777; FungiDB:YKR069W; VEuPathDB:YKR069W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
MET20
Summary
Enables uroporphyrin-III C-methyltransferase activity. Involved in siroheme biosynthetic process. Located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See MET1 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (571612..573393)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene bifunctional glycerol-3-phosphate/glycerone-phosphate O-acyltransferase GPT2 Neighboring gene TRAPP complex core subunit BET3 Neighboring gene uncharacterized protein Neighboring gene electron carrier DRE2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The role of Saccharomyces cerevisiae Met1p and Met8p in sirohaem and cobalamin biosynthesis. Raux E, et al. Biochem J, 1999 Mar 15. PMID 10051442, Free PMC Article
  2. Physiological analysis of mutants of Saccharomyces cerevisiae impaired in sulphate assimilation. Thomas D, et al. J Gen Microbiol, 1992 Oct. PMID 1479340
  3. Sulfate assimilation regulates hydrogen sulfide production independent of lifespan and reactive oxygen species under methionine restriction condition in yeast. Choi KM, et al. Aging (Albany NY), 2019 Jun 29. PMID 31254461, Free PMC Article
  4. Siroheme biosynthesis in Saccharomyces cerevisiae requires the products of both the MET1 and MET8 genes. Hansen J, et al. FEBS Lett, 1997 Jan 13. PMID 9003798
  5. Complex modifier landscape underlying genetic background effects. Hou J, et al. Proc Natl Acad Sci U S A, 2019 Mar 12. PMID 30804202, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables uroporphyrin-III C-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables uroporphyrin-III C-methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables uroporphyrin-III C-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in methionine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in porphyrin-containing compound biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in siroheme biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in siroheme biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in siroheme biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sulfate assimilation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
uroporphyrinogen-III C-methyltransferase
NP_012995.3
  • S-adenosyl-L-methionine uroporphyrinogen III transmethylase; involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    571612..573393
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179859.3 → NP_012995.3  TPA: uroporphyrinogen-III C-methyltransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012995.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXD0, P36150
    UniProtKB/TrEMBL
    G2WI97
    Conserved Domains (2) summary
    COG0007
    Location:323 → 566
    CysG; Uroporphyrinogen-III methylase (siroheme synthase) [Coenzyme transport and metabolism]
    COG1648
    Location:5 → 288
    CysG2; Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P36150.1

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