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DAD2 Dad2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853958, updated on 18-Sep-2024

Summary

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Official Symbol
DAD2
Official Full Name
Dad2p
Primary source
SGD:S000001791
Locus tag
YKR083C
See related
AllianceGenome:SGD:S000001791; FungiDB:YKR083C; VEuPathDB:YKR083C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
HSK1
Summary
Contributes to microtubule plus-end binding activity. Involved in attachment of spindle microtubules to kinetochore; positive regulation of attachment of spindle microtubules to kinetochore; and positive regulation of microtubule polymerization. Part of DASH complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See DAD2 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (596421..596822, complement)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene rRNA-binding ribosome biosynthesis protein RPF2 Neighboring gene Nup133p Neighboring gene ribosome dissociation factor GTPase HBS1 Neighboring gene mitochondrial 54S ribosomal protein YmL20

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A simple and inexpensive quantitative technique for determining chemical sensitivity in Saccharomyces cerevisiae. Hung CW, et al. Sci Rep, 2018 Aug 9. PMID 30093662, Free PMC Article
  2. A method for reverse interactome analysis: High-resolution mapping of interdomain interaction network in Dam1 complex and its specific disorganization based on the interaction domain expression. Ikeuchi A, et al. Biotechnol Prog, 2010 Jul-Aug. PMID 20730753
  3. Implication of a novel multiprotein Dam1p complex in outer kinetochore function. Cheeseman IM, et al. J Cell Biol, 2001 Dec 24. PMID 11756468, Free PMC Article
  4. Molecular architecture of the Dam1 complex-microtubule interaction. Legal T, et al. Open Biol, 2016 Mar. PMID 26962051, Free PMC Article
  5. Kinetochores require oligomerization of Dam1 complex to maintain microtubule attachments against tension and promote biorientation. Umbreit NT, et al. Nat Commun, 2014 Sep 19. PMID 25236177, Free PMC Article

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to microtubule plus-end binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in attachment of spindle microtubules to kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in attachment of spindle microtubules to kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome segregation IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of attachment of spindle microtubules to kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of microtubule polymerization IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of DASH complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of DASH complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of DASH complex IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in mitotic spindle IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitotic spindle midzone IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitotic spindle pole body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in spindle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Dad2p
NP_013009.1
  • Essential subunit of the Dam1 complex (aka DASH complex); complex couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    596421..596822 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179873.1 → NP_013009.1  TPA: Dad2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013009.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXE3, P36162
    UniProtKB/TrEMBL
    A7A042, G2WIB0
    Conserved Domains (1) summary
    pfam08654
    Location:6 → 129
    DASH_Dad2; DASH complex subunit Dad2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P36162.1

Gene LinkOut

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