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SRL3 DNA-binding protein SRL3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853966, updated on 2-Nov-2024

Summary

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Official Symbol
SRL3
Official Full Name
DNA-binding protein SRL3
Primary source
SGD:S000001799
Locus tag
YKR091W
See related
AllianceGenome:SGD:S000001799; FungiDB:YKR091W; VEuPathDB:YKR091W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
WHI7
Summary
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in nucleobase-containing compound metabolic process. Located in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See SRL3 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (611525..612265)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene triacylglycerol lipase Neighboring gene Pxl1p Neighboring gene Srp40p Neighboring gene Ptr2p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The CDK Pho85 inhibits Whi7 Start repressor to promote cell cycle entry in budding yeast. Ros-Carrero C, et al. EMBO Rep, 2024 Feb. PMID 38233717, Free PMC Article
  2. The available SRL3 deletion strain of Saccharomyces cerevisiae contains a truncation of DNA damage tolerance protein Mms2: Implications for Srl3 and Mms2 functions. Kim E, et al. Internet J Microbiol, 2009. PMID 24795789, Free PMC Article
  3. The budding yeast Start repressor Whi7 differs in regulation from Whi5, emerging as a major cell cycle brake in response to stress. Méndez E, et al. J Cell Sci, 2020 Dec 21. PMID 33443080, Free PMC Article
  4. Mitochondrial phosphatidylethanolamine synthesis affects mitochondrial energy metabolism and quiescence entry through attenuation of Snf1/AMPK signaling in yeast. Miyata N, et al. FASEB J, 2022 Jul. PMID 35639425
  5. Repression of G1/S transcription is mediated via interaction of the GTB motifs of Nrm1 and Whi5 with Swi6. Travesa A, et al. Mol Cell Biol, 2013 Apr. PMID 23382076, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The CDK Pho85 inhibits Whi7 Start repressor to promote cell cycle entry in budding yeast.
    Title: The CDK Pho85 inhibits Whi7 Start repressor to promote cell cycle entry in budding yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleobase-containing compound metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of SBF transcription complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DNA-binding protein SRL3
NP_013017.2
  • Transcriptional repressor at START; binds to SBF (Swi4p-Swi6p) at SCB promoter elements in G1 to repress transcription; START inhibitor that retains Cdc28-Cln3 at the ER; acts with Ydj1p to promote release of the complex in a growth-mediated positive feedback loop to trigger START; unstable and degraded by SCF-Grr1 after phosphorylation; contains a G1/S transcription factor binding (GTB) motif; binds SBF-regulated promoters in HU-treated cells; substrate of Cdc28p and Pho85p; hyperphosphorylated

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    611525..612265
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179881.1 → NP_013017.2  TPA: DNA-binding protein SRL3 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013017.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXF1, P36167
    UniProtKB/TrEMBL
    G2WIB8
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P36167.2

Gene LinkOut

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