PFK27 6-phosphofructo-2-kinase [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: PFK27
Official Full Name: 6-phosphofructo-2-kinase
Primary source: SGD:S000005496
Locus tag: YOL136C
See related: AllianceGenome:SGD:S000005496; FungiDB:YOL136C; VEuPathDB:YOL136C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to enable 6-phosphofructo-2-kinase activity and fructose-2,6-bisphosphate 2-phosphatase activity. Involved in fructose 2,6-bisphosphate metabolic process and regulation of glycolytic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Oct 2024]
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Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Pfk27 is a metabolic targets of Skp1-Cul1-F-box (SCF) ubiquitin ligase.
Title: A proteomic screen reveals SCFGrr1 targets that regulate the glycolytic-gluconeogenic switch.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables 6-phosphofructo-2-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 6-phosphofructo-2-kinase activity	IEA Inferred from Electronic Annotation more info
enables 6-phosphofructo-2-kinase activity	ISA Inferred from Sequence Alignment more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables fructose-2,6-bisphosphate 2-phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in carbohydrate phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in fructose 2,6-bisphosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fructose 2,6-bisphosphate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in fructose 2,6-bisphosphate metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fructose metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of glycolytic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of glycolytic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IC Inferred by Curator more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

NP_014505.1

6-phosphofructo-2-kinase; catalyzes synthesis of fructose-2,6-bisphosphate; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, expression induced by glucose and sucrose, transcriptional regulation involves protein kinase A