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MED7 mediator complex subunit MED7 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853985, updated on 18-Sep-2024

Summary

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Official Symbol
MED7
Official Full Name
mediator complex subunit MED7
Primary source
SGD:S000005495
Locus tag
YOL135C
See related
AllianceGenome:SGD:S000005495; FungiDB:YOL135C; VEuPathDB:YOL135C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables transcription coactivator activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Part of core mediator complex. Orthologous to human MED7 (mediator complex subunit 7). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See MED7 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (69376..70044, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Bsc6p Neighboring gene 6-phosphofructo-2-kinase Neighboring gene SCF ubiquitin ligase complex subunit HRT1 Neighboring gene 1,3-beta-glucanosyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sequence analysis of a 12 801 bp fragment of the left arm of yeast chromosome XV containing a putative 6-phosphofructo-2-kinase gene, a gene for a possible glycophospholipid-anchored surface protein and six other open reading frames. Aldea M, et al. Yeast, 1996 Sep. PMID 8896270
  2. Mediator protein mutations that selectively abolish activated transcription. Myers LC, et al. Proc Natl Acad Sci U S A, 1999 Jan 5. PMID 9874773, Free PMC Article
  3. Fungal mediator tail subunits contain classical transcriptional activation domains. Liu Z, et al. Mol Cell Biol, 2015 Apr. PMID 25645928, Free PMC Article
  4. Role of Mediator in regulating Pol II elongation and nucleosome displacement in Saccharomyces cerevisiae. Kremer SB, et al. Genetics, 2012 May. PMID 22377631, Free PMC Article
  5. Functional and physical interactions within the middle domain of the yeast mediator. Hallberg M, et al. Mol Genet Genomics, 2006 Aug. PMID 16758199

See all (89) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of core mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of core mediator complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mediator complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
mediator complex subunit MED7
NP_014506.1
  • Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    69376..70044 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183389.1 → NP_014506.1  TPA: mediator complex subunit MED7 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014506.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1T4, Q08278
    UniProtKB/TrEMBL
    A6ZN77, B3LIT2, B5VRC6, C7GV10, C8ZHI2, G2WMA3, N1NYH4
    Conserved Domains (1) summary
    pfam05983
    Location:21 → 203
    Med7; MED7 protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08278.1

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