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YGK3 serine/threonine protein kinase YGK3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853992, updated on 2-Nov-2024

Summary

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Official Symbol
YGK3
Official Full Name
serine/threonine protein kinase YGK3
Primary source
SGD:S000005488
Locus tag
YOL128C
See related
AllianceGenome:SGD:S000005488; FungiDB:YOL128C; VEuPathDB:YOL128C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables protein serine/threonine kinase activity. Involved in proteolysis. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See YGK3 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (78352..79479, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Mg(2+) transporter ALR1 Neighboring gene Vps68p Neighboring gene ribosomal 60S subunit protein L25 Neighboring gene malate dehydrogenase MDH2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. In silico evidence for functional specialization after genome duplication in yeast. Turunen O, et al. FEMS Yeast Res, 2009 Feb. PMID 19133069, Free PMC Article
  2. Sequence analysis of a 13.4 kbp fragment from the left arm of chromosome XV reveals a malate dehydrogenase gene, a putative Ser/Thr protein kinase, the ribosomal L25 gene and four new open reading frames. Casamayor A, et al. Yeast, 1996 Sep. PMID 8896265
  3. Phosphorylation of the Gα protein Gpa2 promotes protein kinase A signaling in yeast. Huang S, et al. J Biol Chem, 2019 Dec 6. PMID 31690628, Free PMC Article
  4. The Saccharomyces cerevisiae GSK-3 beta homologs. Kassir Y, et al. Curr Drug Targets, 2006 Nov. PMID 17100585
  5. Yeast glycogen synthase kinase-3 activates Msn2p-dependent transcription of stress responsive genes. Hirata Y, et al. Mol Biol Cell, 2003 Jan. PMID 12529445, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity HDA PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
serine/threonine protein kinase YGK3
NP_014513.1
  • Protein kinase related to mammalian GSK-3 glycogen synthase kinases; GSK-3 homologs (Mck1p, Rim11p, Mrk1p, Ygk3p) are involved in control of Msn2p-dependent transcription of stress responsive genes and in protein degradation; YGK3 has a paralog, MCK1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    78352..79479 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183382.1 → NP_014513.1  TPA: serine/threonine protein kinase YGK3 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014513.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1U0, Q12222
    UniProtKB/TrEMBL
    A6ZN83, C7GV04, N1NVV3
    Conserved Domains (2) summary
    smart00220
    Location:44 → 329
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14137
    Location:35 → 332
    STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12222.1

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