U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

RPL18A ribosomal 60S subunit protein L18A [ Saccharomyces cerevisiae S288C ]

Gene ID: 854029, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
RPL18A
Official Full Name
ribosomal 60S subunit protein L18A
Primary source
SGD:S000005480
Locus tag
YOL120C
See related
AllianceGenome:SGD:S000005480; FungiDB:YOL120C; VEuPathDB:YOL120C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
RP28A
Summary
Predicted to enable RNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Part of cytosolic large ribosomal subunit. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 18. Orthologous to human RPL18 (ribosomal protein L18). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See RPL18A in Genome Data Viewer
Location:
chromosome: XV
Exon count:
2
Sequence:
Chromosome: XV; NC_001147.6 (93395..94402, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene divalent metal ion transporter SMF1 Neighboring gene ribosomal 40S subunit protein S19A Neighboring gene Mch4p Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. RNAse III-mediated degradation of unspliced pre-mRNAs and lariat introns. Danin-Kreiselman M, et al. Mol Cell, 2003 May. PMID 12769851
  2. Functional analysis of a duplicated linked pair of ribosomal protein genes in Saccharomyces cerevisiae. Donovan DM, et al. Mol Cell Biol, 1990 Nov. PMID 2233736, Free PMC Article
  3. Genetic mapping of two pairs of linked ribosomal protein genes in Saccharomyces cerevisiae. Papciak SM, et al. Curr Genet, 1987. PMID 3329973
  4. Structure and organization of two linked ribosomal protein genes in yeast. Molenaar CM, et al. Nucleic Acids Res, 1984 Oct 11. PMID 6387623, Free PMC Article
  5. Coordinated Ribosomal L4 Protein Assembly into the Pre-Ribosome Is Regulated by Its Eukaryote-Specific Extension. Stelter P, et al. Mol Cell, 2015 Jun 4. PMID 25936803, Free PMC Article

See all (85) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IC
Inferred by Curator
more info
 PubMed 
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic translation IC
Inferred by Curator
more info
 PubMed 
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intracellular non-membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
ribosomal 60S subunit protein L18A
NP_014521.1
  • Ribosomal 60S subunit protein L18A; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18A has a paralog, RPL18B, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    93395..94402 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183374.1 → NP_014521.1  TPA: ribosomal 60S subunit protein L18A [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014521.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0P3, P07279, P0CX49, P0CX50
    UniProtKB/TrEMBL
    A6ZN91, B3LIU6, C8ZGM2, G2WLG7, N1NWY0
    Conserved Domains (1) summary
    pfam17135
    Location:2 → 186
    Ribosomal_L18; Ribosomal protein 60S L18 and 50S L18e
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0CX49.1
P0CX50.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Miscellaneous