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MSH2 mismatch repair ATPase MSH2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854063, updated on 3-Nov-2024

Summary

Official Symbol
MSH2
Official Full Name
mismatch repair ATPase MSH2
Primary source
SGD:S000005450
Locus tag
YOL090W
See related
AllianceGenome:SGD:S000005450; FungiDB:YOL090W; VEuPathDB:YOL090W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
PMS5
Summary
Enables ATP binding activity; ATP hydrolysis activity; and DNA secondary structure binding activity. Contributes to DNA binding activity. Involved in DNA metabolic process and silent mating-type cassette heterochromatin formation. Located in nuclear chromosome. Part of MutSalpha complex and MutSbeta complex. Used to study Lynch syndrome (multiple); cancer (multiple); and ovarian disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including Lynch syndrome (multiple); gastrointestinal system cancer (multiple); lung cancer (multiple); mismatch repair cancer syndrome; and transitional cell carcinoma. Orthologous to human MSH2 (mutS homolog 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See MSH2 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (147382..150276)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene cationic amino acid transporter Neighboring gene Spo21p Neighboring gene Hal9p Neighboring gene protein disulfide isomerase MPD2

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Process Evidence Code Pubs
involved_in DNA metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in interstrand cross-link repair IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in meiotic gene conversion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in meiotic mismatch repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mismatch repair IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mismatch repair IEA
Inferred from Electronic Annotation
more info
 
involved_in mismatch repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic recombination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitotic recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in removal of nonhomologous ends IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in removal of nonhomologous ends IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in replication fork arrest IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in silent mating-type cassette heterochromatin formation IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of MutSalpha complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of MutSalpha complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of MutSbeta complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in nuclear chromosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
mismatch repair ATPase MSH2
NP_014551.1
  • Protein that binds to DNA mismatches; forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity and involved in interstrand cross-link repair; Msh2p-Msh6p binds to and hydrolyzes ATP; required for silencing at the silent mating-type loci and telomeres

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    147382..150276
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183344.1NP_014551.1  TPA: mismatch repair ATPase MSH2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014551.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1X8, P25847, Q12423
    UniProtKB/TrEMBL
    B3LIX3, N1P404
    Conserved Domains (1) summary
    COG0249
    Location:11929
    MutS; DNA mismatch repair ATPase MutS [Replication, recombination and repair]