AVO1 Avo1p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: AVO1
Gene description: Avo1p
Primary source: FungiDB:YOL078W
Locus tag: YOL078W
See related: SGD:S000005438; AllianceGenome:SGD:S000005438; VEuPathDB:YOL078W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables phosphatidylinositol-4,5-bisphosphate binding activity. Involved in establishment or maintenance of actin cytoskeleton polarity and regulation of cell growth. Located in cytoplasm and plasma membrane. Part of TORC2 complex. Orthologous to human MAPKAP1 (MAPK associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See AVO1 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (181682..185212)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

structures show that the C-termini of Avo1 and Sin1 both have the pleckstrin homology (PH) domain fold
Title: Structures of the pleckstrin homology domain of Saccharomyces cerevisiae Avo1 and its human orthologue Sin1, an essential subunit of TOR complex 2.
Direct Avo1-Ypk2 interaction is crucial for TORC2 signaling to the downstream Ypk2 pathway.
Title: Target of rapamycin complex 2 signals to downstream effector yeast protein kinase 2 (Ypk2) through adheres-voraciously-to-target-of-rapamycin-2 protein 1 (Avo1) in Saccharomyces cerevisiae.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables molecular adaptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables phosphatidylinositol-4,5-bisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-4,5-bisphosphate binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in TORC2 signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment or maintenance of actin cytoskeleton polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of actin cytoskeleton polarity	IPI Inferred from Physical Interaction more info	PubMed
involved_in regulation of cell growth	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of TORC2 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of TORC2 complex	IEA Inferred from Electronic Annotation more info
part_of TORC2 complex	IPI Inferred from Physical Interaction more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IPI Inferred from Physical Interaction more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in vacuolar membrane	IEA Inferred from Electronic Annotation more info
located_in vacuole	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Avo1p

NP_014563.1

Subunit of TORC2, a regulator of plasma membrane (PM) homeostasis; C-terminal PH domain binds to phosphoinositide-(4,5)-bisphosphate (PI(4,5)P2); binds directly to Ypk2p a Tor2p substrate and downstream TORC2 effector through a conserved central CRIM domain; acts with Tsc11p as a scaffold important for the integrity of the TORC2 complex; dispensable for PM localization of TORC2; role in regulating actin organization and growth control; orthologous to human MAPKAP1/SIN1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

181682..185212

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183332.1 → NP_014563.1 TPA: Avo1p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014563.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W1Y9, Q08236

UniProtKB/TrEMBL

A0A8H4F799, C7GK44, N1NWC9

Conserved Domains (2) summary

cd13331
Location:1066 → 1172

PH_Avo1; Avo1 Pleckstrin homology (PH) domain

pfam16978
Location:638 → 786

CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain