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MDM20 Mdm20p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854079, updated on 2-Nov-2024

Summary

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Official Symbol
MDM20
Official Full Name
Mdm20p
Primary source
SGD:S000005436
Locus tag
YOL076W
See related
AllianceGenome:SGD:S000005436; FungiDB:YOL076W; VEuPathDB:YOL076W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
DEC1; NAA25
Summary
Contributes to peptide alpha-N-acetyltransferase activity. Involved in several processes, including N-terminal peptidyl-methionine acetylation; mitochondrion inheritance; and regulation of actin cytoskeleton organization. Part of NatB complex. Orthologous to human NAA25 (N-alpha-acetyltransferase 25, NatB auxiliary subunit). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See MDM20 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (187024..189414)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene F1F0 ATP synthase subunit k Neighboring gene ribosome biogenesis protein BRX1 Neighboring gene uncharacterized protein Neighboring gene Dsc2p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The dynamin-related GTPase Dnm1 regulates mitochondrial fission in yeast. Bleazard W, et al. Nat Cell Biol, 1999 Sep. PMID 10559943, Free PMC Article
  2. Suppressors of mdm20 in yeast identify new alleles of ACT1 and TPM1 predicted to enhance actin-tropomyosin interactions. Singer JM, et al. Genetics, 2000 Oct. PMID 11014803, Free PMC Article
  3. Mdm20 protein functions with Nat3 protein to acetylate Tpm1 protein and regulate tropomyosin-actin interactions in budding yeast. Singer JM, et al. Proc Natl Acad Sci U S A, 2003 Jun 24. PMID 12808144, Free PMC Article
  4. Nat3p and Mdm20p are required for function of yeast NatB Nalpha-terminal acetyltransferase and of actin and tropomyosin. Polevoda B, et al. J Biol Chem, 2003 Aug 15. PMID 12783868
  5. Improper organization of the actin cytoskeleton affects protein synthesis at initiation. Gross SR, et al. Mol Cell Biol, 2007 Mar. PMID 17178834, Free PMC Article

See all (63) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables acetyltransferase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to peptide alpha-N-acetyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in N-terminal peptidyl-methionine acetylation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in N-terminal peptidyl-methionine acetylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrion inheritance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mitochondrion inheritance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of actin cytoskeleton organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of NatB complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of NatB complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Mdm20p
NP_014566.1
  • Non-catalytic subunit of the NatB N-terminal acetyltransferase; NatB catalyzes N-acetylation of proteins with specific N-terminal sequences; involved in mitochondrial inheritance and actin assembly

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    187024..189414
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183330.1 → NP_014566.1  TPA: Mdm20p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014566.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1Z2, Q12387
    UniProtKB/TrEMBL
    A6ZND5, N1NZ50
    Conserved Domains (1) summary
    pfam09797
    Location:270 → 591
    NatB_MDM20; N-acetyltransferase B complex (NatB) non catalytic subunit
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12387.1

Gene LinkOut

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