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SDH5 succinate dehydrogenase assembly factor SDH5 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854083, updated on 2-Nov-2024

Summary

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Official Symbol
SDH5
Official Full Name
succinate dehydrogenase assembly factor SDH5
Primary source
SGD:S000005432
Locus tag
YOL071W
See related
AllianceGenome:SGD:S000005432; FungiDB:YOL071W; VEuPathDB:YOL071W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
EMI5
Summary
Involved in mitochondrial respiratory chain complex II assembly; protein flavinylation; and tricarboxylic acid cycle. Located in mitochondrion. Is active in mitochondrial matrix. Used to study paraganglioma. Human ortholog(s) of this gene implicated in paraganglioma. Orthologous to human SDHAF2 (succinate dehydrogenase complex assembly factor 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See SDH5 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (196507..196995)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Dsc2p Neighboring gene Thp1p Neighboring gene Nba1p Neighboring gene kinetochore-associated Ndc80 complex subunit NUF2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Solution NMR structure of yeast succinate dehydrogenase flavinylation factor Sdh5 reveals a putative Sdh1 binding site. Eletsky A, et al. Biochemistry, 2012 Oct 30. PMID 23062074, Free PMC Article
  2. Complete Native Stable Isotope Labeling by Amino Acids of Saccharomyces cerevisiae for Global Proteomic Analysis. Dannenmaier S, et al. Anal Chem, 2018 Sep 4. PMID 30102515, Free PMC Article
  3. Flavinylation and assembly of succinate dehydrogenase are dependent on the C-terminal tail of the flavoprotein subunit. Kim HJ, et al. J Biol Chem, 2012 Nov 23. PMID 23043141, Free PMC Article
  4. Emerging concepts in the flavinylation of succinate dehydrogenase. Kim HJ, et al. Biochim Biophys Acta, 2013 May. PMID 23380393, Free PMC Article
  5. Pseudomonas-Saccharomyces interactions: influence of fungal metabolism on bacterial physiology and survival. Romano JD, et al. J Bacteriol, 2005 Feb. PMID 15659672, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Studies indicate that the flavinylation factor Sdh5 provided insight into the possible mechanism associated with Sdh1 flavinylation.
    Title: Emerging concepts in the flavinylation of succinate dehydrogenase.
  2. The NMR structure of Sdh5 represents the first eukaryotic structure of Pfam family PF03937 and reveals a conserved surface region, which likely represents a putative Sdh1-Sdh5 interaction interface.
    Title: Solution NMR structure of yeast succinate dehydrogenase flavinylation factor Sdh5 reveals a putative Sdh1 binding site.
  3. Sdh5 (originally named EMI5/YOL071W)is required for succinate dehydrogenase(SDH)-dependent respiration and for Sdh1 flavination
    Title: SDH5, a gene required for flavination of succinate dehydrogenase, is mutated in paraganglioma.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in ascospore formation HMP PubMed 
involved_in mitochondrial electron transport, succinate to ubiquinone IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial electron transport, succinate to ubiquinone IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial respiratory chain complex II assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial respiratory chain complex II assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein flavinylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein-FAD linkage IEA
Inferred from Electronic Annotation
more info
  
involved_in tricarboxylic acid cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tricarboxylic acid cycle IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
succinate dehydrogenase assembly factor SDH5
NP_014570.1
  • Protein required for flavinylation of Sdh1p; binds to Sdh1p and promotes FAD cofactor attachment, which is necessary for succinate dehydrogenase (SDH) complex assembly and activity; mutations in human ortholog PGL2 are associated with neuroendocrine tumors (paraganglioma)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    196507..196995
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183326.1 → NP_014570.1  TPA: succinate dehydrogenase assembly factor SDH5 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014570.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6ZND9, B3LIY9, D6W1Z6, Q08230
    UniProtKB/TrEMBL
    C7GK38, C8ZHP4, G2WMG3, N1NXN8
    Conserved Domains (1) summary
    COG2938
    Location:52 → 150
    SdhE; Succinate dehydrogenase flavin-adding protein, antitoxin component of the CptAB toxin-antitoxin module [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08230.1

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