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CRT10 Crt10p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854091, updated on 2-Nov-2024

Summary

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Official Symbol
CRT10
Official Full Name
Crt10p
Primary source
SGD:S000005424
Locus tag
YOL063C
See related
AllianceGenome:SGD:S000005424; FungiDB:YOL063C; VEuPathDB:YOL063C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in nonfunctional rRNA decay. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See CRT10 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (207392..210265, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene phosphoinositide 5-phosphatase INP54 Neighboring gene 3'(2'),5'-bisphosphate nucleotidase Neighboring gene Apm4p Neighboring gene ribose phosphate diphosphokinase subunit PRS5

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification and characterization of CRT10 as a novel regulator of Saccharomyces cerevisiae ribonucleotide reductase genes. Fu Y, et al. Nucleic Acids Res, 2006. PMID 16600900, Free PMC Article
  2. Rtt101 and Mms1 in budding yeast form a CUL4(DDB1)-like ubiquitin ligase that promotes replication through damaged DNA. Zaidi IW, et al. EMBO Rep, 2008 Oct. PMID 18704118, Free PMC Article
  3. 2'-O-ribose methylation of transfer RNA promotes recovery from oxidative stress in Saccharomyces cerevisiae. Endres L, et al. PLoS One, 2020. PMID 32053677, Free PMC Article
  4. Crt10 directs the cullin-E3 ligase Rtt101 to nonfunctional 25S rRNA decay. Sakata T, et al. Biochem Biophys Res Commun, 2015 Jan 30. PMID 25534857
  5. Remodeling of the SCF complex-mediated ubiquitination system by compositional alteration of incorporated F-box proteins. Kato M, et al. Proteomics, 2010 Jan. PMID 19882662

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CRT10 is involved in the transcriptional regulation of ribonucleotide reductase genes.
    Title: Identification and characterization of CRT10 as a novel regulator of Saccharomyces cerevisiae ribonucleotide reductase genes.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in nonfunctional rRNA decay IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in nonfunctional rRNA decay IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
Crt10p
NP_014578.1
  • Protein required for the degradation of mutant 25S rRNAs; functions in Mms1 pathway of nonfunctional 25S rRNA decay; expression induced by DNA damage and null mutations confer increased resistance to hydroxyurea; N-terminal region has a leucine repeat and a WD40 repeat

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    207392..210265 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183318.1 → NP_014578.1  TPA: Crt10p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014578.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W204, Q08226, Q6B2N4, Q7LGP7
    UniProtKB/TrEMBL
    N1P431
    Conserved Domains (1) summary
    pfam08728
    Location:127 → 948
    CRT10
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08226.1

Gene LinkOut

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