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MAM3 Mam3p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854094, updated on 2-Nov-2024

Summary

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Official Symbol
MAM3
Official Full Name
Mam3p
Primary source
SGD:S000005421
Locus tag
YOL060C
See related
AllianceGenome:SGD:S000005421; FungiDB:YOL060C; VEuPathDB:YOL060C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable transmembrane transporter activity. Involved in intracellular manganese ion homeostasis and mitochondrion organization. Acts upstream of or within intracellular magnesium ion homeostasis. Located in endoplasmic reticulum and fungal-type vacuole membrane. Human ortholog(s) of this gene implicated in Jalili syndrome and renal hypomagnesemia 6. Orthologous to several human genes including CNNM1 (cyclin and CBS domain divalent metal cation transport mediator 1); CNNM2 (cyclin and CBS domain divalent metal cation transport mediator 2); and CNNM3 (cyclin and CBS domain divalent metal cation transport mediator 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See MAM3 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (214017..216137, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Apm4p Neighboring gene ribose phosphate diphosphokinase subunit PRS5 Neighboring gene glycerol-3-phosphate dehydrogenase (NAD(+)) GPD2 Neighboring gene argininosuccinate synthase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Phenotypic switching in Candida glabrata involves phase-specific regulation of the metallothionein gene MT-II and the newly discovered hemolysin gene HLP. Lachke SA, et al. Infect Immun, 2000 Feb. PMID 10639459, Free PMC Article
  2. Conserved mechanism for vacuolar magnesium sequestration in yeast and plant cells. Tang RJ, et al. Nat Plants, 2022 Feb. PMID 35087208
  3. A genome-wide immunodetection screen in S. cerevisiae uncovers novel genes involved in lysosomal vacuole function and morphology. Ricarte F, et al. PLoS One, 2011. PMID 21912603, Free PMC Article
  4. Functional analysis of 150 deletion mutants in Saccharomyces cerevisiae by a systematic approach. Entian KD, et al. Mol Gen Genet, 1999 Dec. PMID 10628851
  5. Get1p and Get2p are required for maintenance of mitochondrial morphology and normal cardiolipin levels. Joshi AS, et al. FEMS Yeast Res, 2016 May. PMID 26926495, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. first report of a eukaryotic ACDP family protein, MAM3, involved in metal homoeostasis
    Title: Manganese toxicity and Saccharomyces cerevisiae Mam3p, a member of the ACDP (ancient conserved domain protein) family.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within intracellular magnesium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular manganese ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in magnesium ion homeostasis IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
located_in fungal-type vacuole membrane HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Mam3p
NP_014581.1
  • Protein involved in magnesium homeostasis; required for Mg2+ sequestration in vacuole; required for normal mitochondrial morphology; has similarity to hemolysins

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    214017..216137 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183315.1 → NP_014581.1  TPA: Mam3p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014581.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W207, Q12296
    UniProtKB/TrEMBL
    A6ZNF0, N1NX85
    Conserved Domains (1) summary
    COG1253
    Location:35 → 396
    TlyC; Hemolysin or related protein, contains CBS domains [General function prediction only]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12296.1

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