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ARG1 argininosuccinate synthase [ Saccharomyces cerevisiae S288C ]

Gene ID: 854096, updated on 3-Nov-2024

Summary

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Official Symbol
ARG1
Official Full Name
argininosuccinate synthase
Primary source
SGD:S000005419
Locus tag
YOL058W
See related
AllianceGenome:SGD:S000005419; FungiDB:YOL058W; VEuPathDB:YOL058W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
ARG10
Summary
Enables argininosuccinate synthase activity. Involved in L-arginine biosynthetic process. Located in cytosol. Human ortholog(s) of this gene implicated in citrullinemia; classic citrullinemia; hepatocellular carcinoma; and melanoma. Orthologous to human ASS1 (argininosuccinate synthase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ARG1 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (219211..220473)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Mam3p Neighboring gene glycerol-3-phosphate dehydrogenase (NAD(+)) GPD2 Neighboring gene dipeptidyl-peptidase III Neighboring gene phosphoglycerate mutase family protein GPM3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Yeast argininosuccinate synthetase. Purification; structural and kinetic properties. Hilger F, et al. Eur J Biochem, 1979 Feb 15. PMID 35347
  2. Genetic mapping of arg1 and arg8 in Saccharomyces cerevisiae by trisomic analysis combined with interallelic complementation. Hilger F, et al. J Bacteriol, 1980 Jan. PMID 6986360, Free PMC Article
  3. Two functional motifs define the interaction, internalization and toxicity of the cell-penetrating antifungal peptide PAF26 on fungal cells. Muñoz A, et al. PLoS One, 2013. PMID 23349973, Free PMC Article
  4. Sensitivity of Saccharomyces cerevisiae to the cell-penetrating antifungal peptide PAF26 correlates with endogenous nitric oxide (NO) production. Carmona L, et al. Biochem Biophys Res Commun, 2012 Jan 6. PMID 22120633
  5. Further definition of the sequence and position requirements of the arginine control element that mediates repression and induction by arginine in Saccharomyces cerevisiae. Crabeel M, et al. Yeast, 1995 Nov. PMID 8585320

See all (59) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. By promoting histone H2B lysine 123 ubiquitylation, Paf1 represses the ARG1 gene by negatively affecting Gcn4 occupancy at the promoter.
    Title: Paf1 restricts Gcn4 occupancy and antisense transcription at the ARG1 promoter.
  2. Mcm1p binding positively regulate ARG1 transcription and cell growth in the absence of arginine and Gcn4p.
    Title: Mcm1p binding sites in the ARG1 promoter positively regulate ARG1 transcription and S. cerevisiae growth in the absence of arginine and Gcn4p.
  3. Mcm1p contributes to active transcription at the ARG1 promoter by increasing the binding of the activator Gcn4p and by recruiting the co-activator complex SWI/SNF at ARG1 under Gcn4p-induced conditions.
    Title: Mcm1p binding sites in ARG1 positively regulate Gcn4p binding and SWI/SNF recruitment.
  4. Gcn4p stimulates binding of Cyc8p/Tup1p at the 3' end of the ARG1 gene.
    Title: Activator Gcn4p and Cyc8p/Tup1p are interdependent for promoter occupancy at ARG1 in vivo.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables argininosuccinate synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables argininosuccinate synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables argininosuccinate synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-arginine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in L-arginine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in L-arginine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in argininosuccinate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in urea cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
argininosuccinate synthase
NP_014583.2
  • Argininosuccinate synthetase; catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway; potential Cdc28p substrate

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    219211..220473
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183313.2 → NP_014583.2  TPA: argininosuccinate synthase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014583.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W209, P22768
    UniProtKB/TrEMBL
    A0A182B5T6, A6ZNF2, B3LJ01, C7GK25, C8ZHQ5, G2WMH6, N1P2Q7
    Conserved Domains (1) summary
    pfam00764
    Location:7 → 406
    Arginosuc_synth; Arginosuccinate synthase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P22768.3

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