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SPE2 adenosylmethionine decarboxylase SPE2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854105, updated on 2-Nov-2024

Summary

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Official Symbol
SPE2
Official Full Name
adenosylmethionine decarboxylase SPE2
Primary source
SGD:S000005412
Locus tag
YOL052C
See related
AllianceGenome:SGD:S000005412; FungiDB:YOL052C; VEuPathDB:YOL052C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables adenosylmethionine decarboxylase activity. Involved in pantothenate biosynthetic process; spermidine biosynthetic process; and spermine biosynthetic process. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human AMD1 (adenosylmethionine decarboxylase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See SPE2 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (232446..233636, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Aim39p Neighboring gene Ddr2p Neighboring gene ncRNA Neighboring gene Gal11p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. S-adenosylmethionine decarboxylase from baker's yeast. Pösö H, et al. Biochem J, 1975 Oct. PMID 1108876, Free PMC Article
  2. Legionella pneumophila requires polyamines for optimal intracellular growth. Nasrallah GK, et al. J Bacteriol, 2011 Sep. PMID 21742865, Free PMC Article
  3. Spermidine or spermine is essential for the aerobic growth of Saccharomyces cerevisiae. Balasundaram D, et al. Proc Natl Acad Sci U S A, 1991 Jul 1. PMID 2062864, Free PMC Article
  4. Polyamine accumulation in transgenic tomato enhances the tolerance to high temperature stress. Cheng L, et al. J Integr Plant Biol, 2009 May. PMID 19508360
  5. Spermidine biosynthesis in Saccharomyces cerevisiae. Biosynthesis and processing of a proenzyme form of S-adenosylmethionine decarboxylase. Kashiwagi K, et al. J Biol Chem, 1990 Dec 25. PMID 2266128

See all (65) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables adenosylmethionine decarboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adenosylmethionine decarboxylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables adenosylmethionine decarboxylase activity IEA
Inferred from Electronic Annotation
more info
  
enables carboxy-lyase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in pantothenate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermidine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermidine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in spermidine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in spermine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
adenosylmethionine decarboxylase SPE2
NP_014590.1
  • S-adenosylmethionine decarboxylase; required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    232446..233636 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183306.1 → NP_014590.1  TPA: adenosylmethionine decarboxylase SPE2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014590.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W216, P21182
    UniProtKB/TrEMBL
    A6ZNF9, B3LJ08, B5VRK0, C7GK18, C8ZHR2, G2WMI3, N1NY29
    Conserved Domains (1) summary
    cl03253
    Location:28 → 396
    SAM_decarbox; Adenosylmethionine decarboxylase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P21182.1

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