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NTG2 bifunctional N-glycosylase/AP lyase NTG2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854114, updated on 2-Nov-2024

Summary

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Official Symbol
NTG2
Official Full Name
bifunctional N-glycosylase/AP lyase NTG2
Primary source
SGD:S000005403
Locus tag
YOL043C
See related
AllianceGenome:SGD:S000005403; FungiDB:YOL043C; VEuPathDB:YOL043C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SCR2
Summary
Enables DNA-(apurinic or apyrimidinic site) endonuclease activity and oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity. Involved in base-excision repair, AP site formation. Located in nucleus. Human ortholog(s) of this gene implicated in familial adenomatous polyposis 3. Orthologous to human NTHL1 (nth like DNA glycosylase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See NTG2 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (248392..249534, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene serine/threonine protein kinase PSK2 Neighboring gene Pex15p Neighboring gene RNA exonuclease Neighboring gene Nop12p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Yeast redoxyendonuclease, a DNA repair enzyme similar to Escherichia coli endonuclease III. Gossett J, et al. Biochemistry, 1988 Apr 5. PMID 2454659
  2. Purification, characterization, gene cloning, and expression of Saccharomyces cerevisiae redoxyendonuclease, a homolog of Escherichia coli endonuclease III. Augeri L, et al. Biochemistry, 1997 Jan 28. PMID 9020769
  3. Saccharomyces cerevisiae possesses two functional homologues of Escherichia coli endonuclease III. You HJ, et al. Biochemistry, 1998 Apr 28. PMID 9558341
  4. Substrate specificities of the ntg1 and ntg2 proteins of Saccharomyces cerevisiae for oxidized DNA bases are not identical. Sentürker S, et al. Nucleic Acids Res, 1998 Dec 1. PMID 9826748, Free PMC Article
  5. The Saccharomyces cerevisiae homologues of endonuclease III from Escherichia coli, Ntg1 and Ntg2, are both required for efficient repair of spontaneous and induced oxidative DNA damage in yeast. Alseth I, et al. Mol Cell Biol, 1999 May. PMID 10207101, Free PMC Article

See all (70) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The intracellular localization of the Saccharomyces cerevisiae N-glycosylase/AP lyases, Ntg1 and Ntg2, in response to nuclear and mitochondrial oxidative stress, was determined.
    Title: Dynamic compartmentalization of base excision repair proteins in response to nuclear and mitochondrial oxidative stress.
  2. The roles of OGG1 and NTG2 genes in the repair of lethal and mutagenic oxidative lesions induced by H2O2 and their relationships with iron and copper ions are discussed.
    Title: Role of OGG1 and NTG2 in the repair of oxidative DNA damage and mutagenesis induced by hydrogen peroxide in Saccharomyces cerevisiae: relationships with transition metals iron and copper.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA N-glycosylase activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-(apurinic or apyrimidinic site) endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-(apurinic or apyrimidinic site) endonuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-(apurinic or apyrimidinic site) endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables class I DNA-(apurinic or apyrimidinic site) endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidized base lesion DNA N-glycosylase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in base-excision repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in base-excision repair IEA
Inferred from Electronic Annotation
more info
  
involved_in base-excision repair, AP site formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in base-excision repair, AP site formation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in base-excision repair, AP site formation IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleotide-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
bifunctional N-glycosylase/AP lyase NTG2
NP_014599.1
  • DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair, localizes to the nucleus; sumoylated; NTG2 has a paralog, NTG1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    248392..249534 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183297.1 → NP_014599.1  TPA: bifunctional N-glycosylase/AP lyase NTG2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014599.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W223, Q08214
    UniProtKB/TrEMBL
    A6ZNG6, B3LJ15, B5VRL0, C7GK12, C8ZHS1, G2WMJ0, N1P2S0
    Conserved Domains (1) summary
    COG0177
    Location:96 → 343
    Nth; Endonuclease III [Replication, recombination and repair]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08214.1

Gene LinkOut

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