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LAG2 Lag2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854133, updated on 18-Sep-2024

Summary

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Official Symbol
LAG2
Official Full Name
Lag2p
Primary source
SGD:S000005385
Locus tag
YOL025W
See related
AllianceGenome:SGD:S000005385; FungiDB:YOL025W; VEuPathDB:YOL025W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
ECM36
Summary
Involved in negative regulation of ubiquitin-protein transferase activity. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See LAG2 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (274957..276939)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Mim1p Neighboring gene tRNA-Ser Neighboring gene uncharacterized protein Neighboring gene translation initiation factor 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. LAG2, a gene that determines yeast longevity. Childress AM, et al. Microbiology (Reading), 1996 Aug. PMID 8760941
  2. Aging in Saccharomyces cerevisiae. Sinclair D, et al. Annu Rev Microbiol, 1998. PMID 9891807
  3. A synthetic lethal screen identifies HDAC4 as a potential target in MELK overexpressing cancers. Zhou L, et al. G3 (Bethesda), 2021 Dec 8. PMID 34550356, Free PMC Article
  4. CSN- and CAND1-dependent remodelling of the budding yeast SCF complex. Zemla A, et al. Nat Commun, 2013. PMID 23535662
  5. Cullin neddylation and substrate-adaptors counteract SCF inhibition by the CAND1-like protein Lag2 in Saccharomyces cerevisiae. Siergiejuk E, et al. EMBO J, 2009 Dec 16. PMID 19942853, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. binding of substrate-specific adaptors triggers release of Cand1/Lag2, whereas subsequent neddylation of the cullin facilitates the removal and prevents re-association of Lag2/Cand1
    Title: Cullin neddylation and substrate-adaptors counteract SCF inhibition by the CAND1-like protein Lag2 in Saccharomyces cerevisiae.
  2. Lag2 disrupts the ubiquitylation activity of the SCF E3 ligase by interrupting the association of Cdc34 to SCF complex.
    Title: A longevity protein, Lag2, interacts with SCF complex and regulates SCF function.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in negative regulation of protein ubiquitination IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
Lag2p
NP_014617.1
  • Protein that negatively regulates the SCF E3-ubiquitin ligase; regulates by interacting with and preventing neddyation of the cullin subunit, Cdc53p; longevity determinant that is preferentially expressed in young cells; similar to mammalian Cand1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    274957..276939
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183279.1 → NP_014617.1  TPA: Lag2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014617.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W240, Q08175, Q92325
    UniProtKB/TrEMBL
    B3LJ32, C7GJZ6, C8ZHT8, N1NWD3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q92325.2

Gene LinkOut

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