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COQ10 ubiquinone-binding protein COQ10 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854154, updated on 2-Nov-2024

Summary

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Official Symbol
COQ10
Official Full Name
ubiquinone-binding protein COQ10
Primary source
SGD:S000005368
Locus tag
YOL008W
See related
AllianceGenome:SGD:S000005368; FungiDB:YOL008W; VEuPathDB:YOL008W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables ubiquinone binding activity. Involved in ubiquinone biosynthetic process. Located in mitochondrial inner membrane. Orthologous to several human genes including COQ10A (coenzyme Q10A). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See COQ10 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (310312..310935)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene rRNA-processing endoribonuclease Neighboring gene ERMES complex subunit MDM12 Neighboring gene Csi2p Neighboring gene DNA topoisomerase 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. [Surface receptors in human lymphocytes]. Nowak J. Pol Arch Med Wewn, 1975 Jul. PMID 50596
  2. The dilemma of diagnosing coenzyme Q(10) deficiency in muscle. Louw R, et al. Mol Genet Metab, 2018 Sep. PMID 29530532
  3. Saccharomyces cerevisiae coq10 null mutants are responsive to antimycin A. Busso C, et al. FEBS J, 2010 Nov. PMID 20875086, Free PMC Article
  4. Human COQ10A and COQ10B are distinct lipid-binding START domain proteins required for coenzyme Q function. Tsui HS, et al. J Lipid Res, 2019 Jul. PMID 31048406, Free PMC Article
  5. COQ11 deletion mitigates respiratory deficiency caused by mutations in the gene encoding the coenzyme Q chaperone protein Coq10. Bradley MC, et al. J Biol Chem, 2020 May 1. PMID 32205446, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. COQ11 deletion mitigates respiratory deficiency caused by mutations in the gene encoding the coenzyme Q chaperone protein Coq10.
    Title: COQ11 deletion mitigates respiratory deficiency caused by mutations in the gene encoding the coenzyme Q chaperone protein Coq10.
  2. We therefore conclude from our data that, to prevent possibly not diagnosing a potential CoQ10 deficiency, the expression of CoQ10 levels in muscle on both CS as well as protein content should be considered.
    Title: The dilemma of diagnosing coenzyme Q(10) deficiency in muscle.
  3. Data suggest that wild-type and coq10 mitochondria accumulate similar amounts of Q(6) semiquinone.
    Title: Saccharomyces cerevisiae coq10 null mutants are responsive to antimycin A.
  4. These results indicate that Coq10p binds Q6 in vivo and that this property is essential for a normal functioning of the electron transport chain.
    Title: Over-expression of COQ10 in Saccharomyces cerevisiae inhibits mitochondrial respiration.
  5. Coq10p is a Q6-binding protein and in the coq10 mutant Q6 it is not able to act as an electron carrier, possibly because of improper localization
    Title: The Saccharomyces cerevisiae COQ10 gene encodes a START domain protein required for function of coenzyme Q in respiration.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular carrier activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquinone binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquinone binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular respiration IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquinone biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ubiquinone-binding protein COQ10
NP_014635.1
  • Coenzyme Q (ubiquinone) binding protein; functions in the delivery of Q<sub>6</sub> to its proper location for electron transport during respiration; START domain protein with homologs in bacteria and eukaryotes; respiratory growth defect of the null mutant is functionally complemented by human COQ10A

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    310312..310935
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183262.1 → NP_014635.1  TPA: ubiquinone-binding protein COQ10 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014635.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W259, Q08058
    UniProtKB/TrEMBL
    A6ZNJ8, B3LJ48, B5VRP5, C7GJW0, C8ZHV7, G2WMM3, N1NWS8
    Conserved Domains (1) summary
    cl14643
    Location:43 → 196
    SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08058.1

Gene LinkOut

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