BUB3 Bub3p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: BUB3
Official Full Name: Bub3p
Primary source: SGD:S000005552
Locus tag: YOR026W
See related: AllianceGenome:SGD:S000005552; FungiDB:YOR026W; VEuPathDB:YOR026W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: PAC9
Summary: Enables ubiquitin binding activity. Involved in mitotic DNA integrity checkpoint signaling and positive regulation of protein autoubiquitination. Located in kinetochore. Part of mitotic checkpoint complex. Orthologous to human BUB3 (BUB3 mitotic checkpoint protein). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See BUB3 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (379781..380806)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Yeast Fin1-PP1 dephosphorylates an Ipl1 substrate, Ndc80, to remove Bub1-Bub3 checkpoint proteins from the kinetochore during anaphase.
Title: Yeast Fin1-PP1 dephosphorylates an Ipl1 substrate, Ndc80, to remove Bub1-Bub3 checkpoint proteins from the kinetochore during anaphase.
Differential requirement for Bub1 and Bub3 in regulation of meiotic versus mitotic chromosome segregation.
Title: Differential requirement for Bub1 and Bub3 in regulation of meiotic versus mitotic chromosome segregation.
Bub3 has a previously unknown function at the kinetochore in activating APC/C-Cdc20 for normal mitotic progression.
Title: Bub3 promotes Cdc20-dependent activation of the APC/C in S. cerevisiae.
Results describe the crystal structure of Bub3p from Saccharomyces cerevisiae at 1.1 angstrom and a crystallographic R-factor of 15.3%, revealing seven authentic repeats.
Title: The 1.1-angstrom structure of the spindle checkpoint protein Bub3p reveals functional regions.
Data describe the crystal structure of the Saccharomyces cerevisiae protein Bub3p at 2.35 angstrom resolution.
Title: Crystal structure of the spindle assembly checkpoint protein Bub3.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ubiquitin binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in mitotic DNA integrity checkpoint signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mitotic spindle assembly checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein autoubiquitination	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of bub1-bub3 complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in kinetochore	IBA Inferred from Biological aspect of Ancestor more info
located_in kinetochore	IDA Inferred from Direct Assay more info	PubMed
part_of mitotic checkpoint complex	IDA Inferred from Direct Assay more info	PubMed
part_of mitotic checkpoint complex	IPI Inferred from Physical Interaction more info	PubMed
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Bub3p

NP_014669.1

Kinetochore checkpoint WD40 repeat protein; localizes to kinetochores during prophase and metaphase, delays anaphase in the presence of unattached kinetochores; forms complexes with Mad1p-Bub1p and with Cdc20p, binds Mad2p and Mad3p; functions at kinetochore to activate APC/C-Cdc20p for normal mitotic progression

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

379781..380806

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183445.1 → NP_014669.1 TPA: Bub3p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014669.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W292, P26449

UniProtKB/TrEMBL

G2WMQ7

Conserved Domains (2) summary

COG2319
Location:2 → 317

WD40; WD40 repeat [General function prediction only]

sd00039
Location:14 → 55

7WD40; WD40 repeat [structural motif]