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STD1 Std1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854212, updated on 29-Jun-2024

Summary

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Gene symbol
STD1
Gene description
Std1p
Primary source
FungiDB:YOR047C
Locus tag
YOR047C
See related
SGD:S000005573; AllianceGenome:SGD:S000005573; VEuPathDB:YOR047C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
MSN3; SFS3
Summary
Enables protein kinase activator activity. Involved in several processes, including glucose metabolic process; pyridine nucleoside biosynthetic process; and response to salt stress. Located in nucleus and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See STD1 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (416347..417681, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Tom6p Neighboring gene ATP-dependent RNA helicase DBP5 Neighboring gene ssRNA exonuclease RAT1 Neighboring gene phospholipid-translocating ATPase RSB1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cross-kingdom chemical communication drives a heritable, mutually beneficial prion-based transformation of metabolism. Jarosz DF, et al. Cell, 2014 Aug 28. PMID 25171409, Free PMC Article
  2. Asymmetric signal transduction through paralogs that comprise a genetic switch for sugar sensing in Saccharomyces cerevisiae. Sabina J, et al. J Biol Chem, 2009 Oct 23. PMID 19720826, Free PMC Article
  3. DNA and protein footprinting analysis of the modulation of DNA binding by the N-terminal domain of the Saccharomyces cerevisiae TATA binding protein. Gupta S, et al. Biochemistry, 2007 Sep 4. PMID 17683121
  4. Isolation of STD1, a high-copy-number suppressor of a dominant negative mutation in the yeast TATA-binding protein. Ganster RW, et al. Mol Cell Biol, 1993 Jun. PMID 8497275, Free PMC Article
  5. STD1 (MSN3) interacts directly with the TATA-binding protein and modulates transcription of the SUC2 gene of Saccharomyces cerevisiae. Tillman TS, et al. Nucleic Acids Res, 1995 Aug 25. PMID 7667094, Free PMC Article

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mth1 and Std1, which are downstream effectors of the Snf3/Rgt2 pathway, were required for viability through mitochondrial function but not fermentative metabolism
    Title: Disruption of Snf3/Rgt2 glucose sensors decreases lifespan and caloric restriction effectiveness through Mth1/Std1 by adjusting mitochondrial efficiency in yeast.
  2. Mth1 is the primary regulator; Std1 serves to buffer the response to glucose.
    Title: Asymmetric signal transduction through paralogs that comprise a genetic switch for sugar sensing in Saccharomyces cerevisiae.
  3. The structural origins of the thermodyn. and kinetic effects of the N-term domain on DNA binding by TBP were explored in studies of TBPc (C-terminal domain of TBP) and TBP by "protein footprinting" with hydroxyl radical (*OH) side chain oxidation.
    Title: DNA and protein footprinting analysis of the modulation of DNA binding by the N-terminal domain of the Saccharomyces cerevisiae TATA binding protein.
  4. RGT2-1 promotes ubiquitination and subsequent degradation of Mth1 and Std1 regardless of the presence of glucose.
    Title: Biochemical evidence for glucose-independent induction of HXT expression in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables protein kinase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in glucose metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nicotinamide riboside biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in nicotinamide riboside biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nicotinic acid riboside biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in nicotinic acid riboside biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to salt stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Std1p
NP_014690.1
  • Protein involved in control of glucose-regulated gene expression; interacts with kinase Snf1p, glucose sensors Snf3p and Rgt2p, TATA-binding Spt15p; regulator of transcription factor Rgt1p; interactions with Pma1p appear to propagate [GAR+]; STD1 has a paralog, MTH1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    416347..417681 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183466.1 → NP_014690.1  TPA: Std1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014690.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2B3, Q02794
    UniProtKB/TrEMBL
    A0A8H4F8Q3, C7GLH5, G2WMS8, N1P2Z7
    Conserved Domains (1) summary
    pfam17235
    Location:154 → 344
    STD1; STD1/MTH1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q02794.1

Gene LinkOut

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