CKA2 casein kinase 2 catalytic subunit CKA2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: CKA2
Official Full Name: casein kinase 2 catalytic subunit CKA2
Primary source: SGD:S000005587
Locus tag: YOR061W
See related: AllianceGenome:SGD:S000005587; FungiDB:YOR061W; VEuPathDB:YOR061W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: YOR29-12
Summary: Enables protein serine/threonine kinase activity. Involved in DNA damage response; donor selection; and regulation of DNA-templated transcription. Part of UTP-C complex and protein kinase CK2 complex. Orthologous to human CSNK2A1 (casein kinase 2 alpha 1); CSNK2A2 (casein kinase 2 alpha 2); and CSNK2A3 (casein kinase 2 alpha 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See CKA2 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (441534..442553)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate that casein kinase 2 (CK2) mediated phosphorylation of chromatin-remodeling histone chaperone SPT6 (Spt6) regulates chromatin dynamics associated with transcription, and prevents aberrant transcription.
Title: Casein kinase 2 mediated phosphorylation of Spt6 modulates histone dynamics and regulates spurious transcription.
Histone H3 threonine 11 phosphorylation by Sch9 and CK2 regulates chronological lifespan by controlling the nutritional stress response.
Title: Histone H3 threonine 11 phosphorylation by Sch9 and CK2 regulates chronological lifespan by controlling the nutritional stress response.
CK2 might positively regulate the general stress response not only by direct phosphorylation of Msn2/4, but also by regulating cellular translocation machinery.
Title: CK2-dependent phosphorylation positively regulates stress-induced activation of Msn2 in Saccharomyces cerevisiae.
The role of Sir2 for dietary restriction-mediated lifespan extension depends on cAMP-protein kinase A (PKA) and casein kinase 2 (CK2) signaling in yeast.
Title: Sir2 phosphorylation through cAMP-PKA and CK2 signaling inhibits the lifespan extension activity of Sir2 in yeast.
These results showed that CKA2 functioned in H2O2-induced apoptosis and high-temperature stress tolerance by regulating nitric oxide synthase-like-dependent nitric oxide accumulation in yeast.
Title: CKA2 functions in H2O2-induced apoptosis and high-temperature stress tolerance by regulating NO accumulation in yeast.
Phosphorylation of the myosin-I Myo5 by cka2 inhibits actin polymerization.
Title: Crosstalk between PI(4,5)P₂and CK2 modulates actin polymerization during endocytic uptake.
Phosphorylation of histone H4 serine 1 during DNA damage requires casein kinase II.
Title: Phosphorylation of histone H4 serine 1 during DNA damage requires casein kinase II in S. cerevisiae.
Yeast transcription elongation factor Elf1 has been identified as a new substrate for protein kinase CK2 and coimmunoprecipitation shows that Elf1 interacts with catalytic (alpha and alpha') as well as regulatory (beta and beta') subunits of CK2.
Title: Yeast elf1 factor is phosphorylated and interacts with protein kinase CK2.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA damage response	IDA Inferred from Direct Assay more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in donor selection	IGI Inferred from Genetic Interaction more info	PubMed
involved_in phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase I	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase III	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of UTP-C complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of protein kinase CK2 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of protein kinase CK2 complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: casein kinase 2 catalytic subunit CKA2

NP_014704.1

EC 2.7.11.1

Alpha' catalytic subunit of casein kinase 2 (CK2); CK2 is a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; protein abundance increases in response to DNA replication stress; regulates Fkh1p-mediated donor preference during mating-type switching

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

441534..442553

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183480.1 → NP_014704.1 TPA: casein kinase 2 catalytic subunit CKA2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014704.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W2C4, P19454

UniProtKB/TrEMBL

A6ZNR3, B3LJB0, B5VRV9, C7GX57, C8ZI22, G2WMT9, N1NWH7

Conserved Domains (1) summary

cd14132
Location:30 → 335

STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2