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GYP1 GTPase-activating protein GYP1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854236, updated on 18-Sep-2024

Summary

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Official Symbol
GYP1
Official Full Name
GTPase-activating protein GYP1
Primary source
SGD:S000005596
Locus tag
YOR070C
See related
AllianceGenome:SGD:S000005596; FungiDB:YOR070C; VEuPathDB:YOR070C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
YOR29-21
Summary
Enables GTPase activator activity. Involved in vesicle-mediated transport. Located in Golgi apparatus. Orthologous to human TBC1D22A (TBC1 domain family member 22A) and TBC1D22B (TBC1 domain family member 22B). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See GYP1 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (455907..457820, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene dolichyl-P-Glc:Glc1Man(9)GlcNAc(2)-PP-dolichol alpha-1,3-glucosyltransferase Neighboring gene Vam10p Neighboring gene sorting nexin 1 Neighboring gene nicotinamide riboside transporter Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification and partial purification of GTPase-activating proteins from yeast and mammalian cells that preferentially act on Ypt1/Rab1 proteins. Tan TJ, et al. FEBS Lett, 1991 Oct 21. PMID 1936282
  2. Crystal structure of the GAP domain of Gyp1p: first insights into interaction with Ypt/Rab proteins. Rak A, et al. EMBO J, 2000 Oct 2. PMID 11013213, Free PMC Article
  3. Identification of regulators for Ypt1 GTPase nucleotide cycling. Jones S, et al. Mol Biol Cell, 1998 Oct. PMID 9763446, Free PMC Article
  4. A Rab prenyl membrane-anchor allows effector recognition to be regulated by guanine nucleotide. Lee M, et al. Proc Natl Acad Sci U S A, 2020 Apr 7. PMID 32213587, Free PMC Article
  5. Establishing a role for the GTPase Ypt1p at the late Golgi. Sclafani A, et al. Traffic, 2010 Apr. PMID 20059749, Free PMC Article

See all (88) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Gyp1 acts as a Ypt1 GTPase-activating protein (GAP) for selective autophagic variants, such as the Cvt pathway or the selective autophagic degradation of mitochondria (mitophagy). Gyp1 regulates the dynamic disassembly of the conserved Ypt1-Atg1 complex. Thereby, Gyp1 sets the stage for efficient Atg14 recruitment, and facilitates the critical step from nucleation to elongation of the phagophore.
    Title: Gyp1 has a dual function as Ypt1 GAP and interaction partner of Atg8 in selective autophagy.
  2. Ypt1p regulates the flow of traffic into the cis and trans side of the Golgi via multiple effectors.
    Title: Establishing a role for the GTPase Ypt1p at the late Golgi.
  3. Data show that Gyp1p, a GAP for Ypt1p, specifically interacts with Ypt32p, and that this interaction is important for the localization and stability of Gyp1p.
    Title: A Rab GAP cascade defines the boundary between two Rab GTPases on the secretory pathway.
  4. crystallographic, mutational and functional analyses of complexes between Rab GTPases and the TBC domain of Gyp1p
    Title: TBC-domain GAPs for Rab GTPases accelerate GTP hydrolysis by a dual-finger mechanism.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in vesicle-mediated transport IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi stack IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
GTPase-activating protein GYP1
NP_014713.1
  • Cis-golgi GTPase-activating protein (GAP) for yeast Rabs; the Rab family members are Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion; interacts with autophagosome component Atg8p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    455907..457820 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183489.1 → NP_014713.1  TPA: GTPase-activating protein GYP1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014713.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2D3, O00028, Q08484
    UniProtKB/TrEMBL
    B3LJB9, B5VRW8, C7GX48, C8ZI31, G2WMU8, N1NYB5
    Conserved Domains (1) summary
    COG5210
    Location:24 → 632
    COG5210; GTPase-activating protein [General function prediction only]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08484.1

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