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Elf1 E74 like ETS transcription factor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 85424, updated on 2-Nov-2024

Summary

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Official Symbol
Elf1provided by RGD
Official Full Name
E74 like ETS transcription factor 1provided by RGD
Primary source
RGD:620697
See related
EnsemblRapid:ENSRNOG00000011762 AllianceGenome:RGD:620697
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in regulation of DNA-templated transcription. Predicted to be active in nucleus. Orthologous to human ELF1 (E74 like ETS transcription factor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 308.9), Spleen (RPKM 189.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Elf1 in Genome Data Viewer
Location:
15q12
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (61354026..61395762)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (54890644..54986721)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (61772544..61868442)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481995 Neighboring gene WW domain binding protein 4 Neighboring gene transfer RNA glutamic acid (anticodon UUC) 8 Neighboring gene microfibrillar-associated protein 1-like Neighboring gene SGT1 homolog, MIS12 kinetochore complex assembly cochaperone Neighboring gene uncharacterized LOC134481994 Neighboring gene chondromodulin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Splice isoforms of transcription factor Elf-1 affecting its regulatory function in transcription-molecular cloning of rat Elf-1. Nishiyama C, et al. Biosci Biotechnol Biochem, 2000 Dec. PMID 11210123
  2. Transcriptional regulation of CD1D1 by Ets family transcription factors. Geng Y, et al. J Immunol, 2005 Jul 15. PMID 16002702
  3. Characterization of NERF, a novel transcription factor related to the Ets factor ELF-1. Oettgen P, et al. Mol Cell Biol, 1996 Sep. PMID 8756667, Free PMC Article
  4. Regulation of ZAP-70 activation and TCR signaling by two related proteins, Sts-1 and Sts-2. Carpino N, et al. Immunity, 2004 Jan. PMID 14738763
  5. Critical role for GATA3 in mediating Tie2 expression and function in large vessel endothelial cells. Song H, et al. J Biol Chem, 2009 Oct 16. PMID 19674970, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of cytokine production ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ETS-related transcription factor Elf-1
Names
E74-like factor 1 (ets domain transcription factor)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053520.2 → NP_445972.2  ETS-related transcription factor Elf-1

    See identical proteins and their annotated locations for NP_445972.2

    Status: VALIDATED

    Source sequence(s)
    AB030215, AB030216, CB782606
    UniProtKB/TrEMBL
    A6HTZ6, G3V9V2, Q9EQY3
    Related
    ENSRNOP00000060815.2, ENSRNOT00000068269.4
    Conserved Domains (3) summary
    smart00413
    Location:206 → 288
    ETS; erythroblast transformation specific domain
    PRK10811
    Location:351 → 531
    rne; ribonuclease E; Reviewed
    pfam12310
    Location:2 → 111
    Elf-1_N; Transcription factor protein N terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    61354026..61395762
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039093704.2 → XP_038949632.1  ETS-related transcription factor Elf-1 isoform X1

    UniProtKB/TrEMBL
    A6HTZ8, A6HTZ9, Q9EQY2, Q9EQY3
    Related
    ENSRNOP00000106538.1, ENSRNOT00000144030.1
    Conserved Domains (3) summary
    smart00413
    Location:170 → 252
    ETS; erythroblast transformation specific domain
    PRK10811
    Location:315 → 495
    rne; ribonuclease E; Reviewed
    pfam12310
    Location:2 → 69
    Elf-1_N; Transcription factor protein N terminal
Nucleotide Protein Strain
Heading Accession and Version

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