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SGO1 Sgo1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854240, updated on 18-Sep-2024

Summary

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Official Symbol
SGO1
Official Full Name
Sgo1p
Primary source
SGD:S000005599
Locus tag
YOR073W
See related
AllianceGenome:SGD:S000005599; FungiDB:YOR073W; VEuPathDB:YOR073W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
YOR29-24
Summary
Involved in several processes, including chromosome organization; meiotic sister chromatid separation; and regulation of chromosome organization. Located in kinetochore. Colocalizes with chromosome, centromeric region. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See SGO1 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (464771..466543)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene tRNA-Pro Neighboring gene thymidylate synthase Neighboring gene Ufe1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Tripartite Chromatin Localization of Budding Yeast Shugoshin Involves Higher-Ordered Architecture of Mitotic Chromosomes. Deng X, et al. G3 (Bethesda), 2018 Aug 30. PMID 30002083, Free PMC Article
  2. Shugoshin biases chromosomes for biorientation through condensin recruitment to the pericentromere. Verzijlbergen KF, et al. Elife, 2014. PMID 24497542, Free PMC Article
  3. Sgo1 is required for co-segregation of sister chromatids during achiasmate meiosis I. Dudas A, et al. Cell Cycle, 2011 Mar 15. PMID 21330786, Free PMC Article
  4. Persistent mechanical linkage between sister chromatids throughout anaphase. Harrison BD, et al. Chromosoma, 2009 Oct. PMID 19603176, Free PMC Article
  5. The many faces of shugoshin, the "guardian spirit," in chromosome segregation. Macy B, et al. Cell Cycle, 2009 Jan 1. PMID 19106605

See all (81) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SUMOylation stabilizes sister kinetochore biorientation to allow timely anaphase.
    Title: SUMOylation stabilizes sister kinetochore biorientation to allow timely anaphase.
  2. Phospho-regulation of the Shugoshin - Condensin interaction at the centromere in budding yeast.
    Title: Phospho-regulation of the Shugoshin - Condensin interaction at the centromere in budding yeast.
  3. The TSM-Sgo1p-cohesin triad is therefore at the center stage of higher-ordered chromatin architecture for error-free segregation.
    Title: Tripartite Chromatin Localization of Budding Yeast Shugoshin Involves Higher-Ordered Architecture of Mitotic Chromosomes.
  4. sgo1 mutants with abolished binding to H2A or PP2A(Rts1) displayed premature SAC silencing.
    Title: Premature Silencing of the Spindle Assembly Checkpoint Is Prevented by the Bub1-H2A-Sgo1-PP2A Axis in Saccharomyces cerevisiae.
  5. Sgo1 operates as a multifunctional hub that coordinates two centromeric functions essential for correct chromosome segregation.
    Title: Sgo1 regulates both condensin and Ipl1/Aurora B to promote chromosome biorientation.
  6. budding yeast shugoshin Sgo1 dissociates from the pericentromere reversibly in response to tension
    Title: Tension-dependent removal of pericentromeric shugoshin is an indicator of sister chromosome biorientation.
  7. Bub1 and Sgo1 act as a rheostat to regulate the chromatin spring and maintain force balance. Through histone H2A S121 phosphorylation and recruitment of Sgo1, Bub1 kinase softens the chromatin spring in response to changes in microtubule dynamics.
    Title: Bub1 kinase and Sgo1 modulate pericentric chromatin in response to altered microtubule dynamics.
  8. found that Sgo1 overexpression rescues defects caused by metaphase inactivation of Mps1 and that Mps1 is required for Sgo1 localization to the kinetochore
    Title: Bub1, Sgo1, and Mps1 mediate a distinct pathway for chromosome biorientation in budding yeast.
  9. Sister kinetochores are frequently bi-oriented in the absence of chiasmata and that Sgo1 prevents equational segregation of sister chromatids during achiasmate meiosis I.
    Title: Sgo1 is required for co-segregation of sister chromatids during achiasmate meiosis I.
  10. Report structure and function of the PP2A-shugoshin interaction.
    Title: Structure and function of the PP2A-shugoshin interaction.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in centromere complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromosome segregation IEA
Inferred from Electronic Annotation
more info
  
involved_in establishment of protein localization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in establishment of protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment of protein localization to chromosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in kinetochore organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in kinetochore organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in maintenance of meiotic sister chromatid cohesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in meiotic chromosome segregation IEA
Inferred from Electronic Annotation
more info
  
involved_in meiotic sister chromatid segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic sister chromatid separation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic cell cycle process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic sister chromatid segregation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mitotic sister chromatid segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic spindle assembly checkpoint signaling IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mitotic spindle assembly checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of maintenance of meiotic sister chromatid cohesion IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of maintenance of meiotic sister chromatid cohesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sister chromatid biorientation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in chromosome, centromeric region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
located_in condensed chromosome, centromeric region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in condensed chromosome, centromeric region IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in spindle pole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Sgo1p
NP_014716.1
  • Component of the spindle checkpoint; involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability; recruits condensin to the pericentric region of chromosomes during meiosis; dissociates from pericentromeres when sister kinetochores are under tension

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    464771..466543
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183492.1 → NP_014716.1  TPA: Sgo1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014716.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2D6, O00031, Q08490
    UniProtKB/TrEMBL
    C7GT42
    Conserved Domains (2) summary
    pfam07557
    Location:366 → 390
    Shugoshin_C; Shugoshin C-terminus
    pfam07558
    Location:43 → 87
    Shugoshin_N; Shugoshin N-terminal coiled-coil region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08490.1

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